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대한류마티스학회> Journal of Rheumatic Diseases(구 대한류마티스학회지)> Clinical Usefulness of Uric Acid as a Biomarker for Knee Osteoarthritis: A Comparative Analysis With Plain Radiography and Musculoskeletal Ultrasound

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Clinical Usefulness of Uric Acid as a Biomarker for Knee Osteoarthritis: A Comparative Analysis With Plain Radiography and Musculoskeletal Ultrasound

Seong-kyu Kim , Ui Hong Jung , Jung-yoon Choe
  • : 대한류마티스학회
  • : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권1호
  • : 연속간행물
  • : 2020년 01월
  • : 51-60(10pages)

DOI


목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
ACKNOWLEDGEMENTS
CONFLICT OF INTEREST
AUTHOR CONTRIBUTIONS
REFERENCES

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Objective. The aim of this study was to determine the relationships of serum and urine uric acid with severity or activity in knee osteoarthritis (OA). Methods. A total of 42 patients with knee OA was enrolled, together with 58 healthy controls. Serum uric acid and spot urine uric acid levels were assessed for all patients. The severity and activity of knee OA were assessed by musculoskeletal ultrasound (MSUS) and plain radiography of the knee joint. Ultrasonographic abnormalities in knee OA includedsynovial hypertrophy, suprapatellar effusion, cartilage degradation, and osteophyte formation. Kellgren-Lawrence (K-L) grade was used to evaluate radiological progression of knee OA. Results. Patients with K-L grade III had a higher urine uric acid/creatinine ratio compared to those with K-L grade I (p=0.043). Patients with synovial hypertrophy had higher serum uric acid level compared to those without synovial hypertrophy (p=0.016). The urine uric acid/creatinine ratio was higher in patients with cartilage degradation compared to those without cartilage degradation (p=0.022). Serum uric acid was significantly associated with synovial hypertrophy thickness (r=0.375, p=0.018) but not with cartilage thickness after adjusting for age and body mass index. Lower urine uric acid was related with knee OA compared to healthy controls (odds ratio=0.974, 95% confidence interval 0.954∼0.994, p=0.013). Conclusion. The results of our study suggest that serum and urine uric acid reflects synovial inflammation based on MSUS and radiographic progression and then is associated with the pathogenesis of knee OA. (J Rheum Dis 2020;27:51-60)

UCI(KEPA)

간행물정보

  • : 의약학분야  > 정형외과학
  • : KCI등재
  • :
  • : 계간
  • : 2093-940X
  • : 2233-4718
  • : 학술지
  • : 연속간행물
  • : 1994-2020
  • : 1344


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2The Use of Biological Disease-modifying Antirheumatic Drugs for Inflammatory Arthritis in Korea: Results of a Korean Expert Consensus

저자 : Eun-jung Park , Hyungjin Kim , Seung Min Jung , Yoon-kyoung Sung , Han Joo Baek , Jisoo Lee

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 4-21 (18 pages)

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Biological disease-modifying antirheumatic drugs (bDMARDs) are highly effective agents for the treatment of inflammatory arthritis; however, they also possess a potential risk for serious infection. Recently, with the rapid expansion of the bDMARDs market in Korea, reports of serious adverse events related to the agents have also increased, necessitating guidance for the use of bDMARDs. Current work entitled, “Expert Consensus for the Use of bDMARDs Drugs for Inflammatory Arthritis in Korea,” is the first to describe the appropriate use of bDMARDs in the management of inflammatory arthritis in Korea, with an aim to provide guidance for the local medical community to improve the quality of clinical care. Twelve consensus statements regarding the use of bDMARDs for the management of rheumatoid arthritis and ankylosing spondylitis were generated. In this review, we provide detailed guidance on bDMARDs use based on expert consensus, including who should prescribe, the role of education, indications for use, and monitoring strategies for safety. (J Rheum Dis 2020;27:4-21)

3Assessments of Functioning in Patients With Axial Spondyloarthritis

저자 : Uta Kiltz , Jurgen Braun

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 22-29 (8 pages)

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A standardized assessment of functioning in patients with axial spondyloarthritis (axSpA) is necessary in order to assess clinical manifestations, disease activity, and physical and overall functioning as objectively as possible. The standardized assessment is based on domains such as disease activity, quality of life, functioning and employment but also on individual aspects such as pain, arthritis and enthesitis. Domains and individual aspects are mainly collected and better known as patient reported outcomes. (J Rheum Dis 2020;27:22-29)

4Echocardiographic Evaluation of Axial Spondyloarthritis in Korea: Data From the Catholic Axial Spondyloarthritis Cohort

저자 : Hong Ki Min , Jennifer Lee , Ji Hyeon Ju , Seung-ki Kwok , Ho-joong Youn , Sung-hwan Park

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 30-36 (7 pages)

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Objective. Axial spondyloarthritis (axSpA) is often accompanied by cardiac manifestations, such as valvular heart disease. In this prospective cohort study, we evaluated the incidence of cardiac abnormalities in Korean axSpA patients by echocardiography. Methods. AxSpA patients were prospectively recruited from a single tertiary hospital. Baseline demographic, clinical, radiographic, and echocardiographic data were collected at the time of enrollment. Echocardiography evaluations were performed with a focus on valvular heart disease and systolic and diastolic function. Logistic regression analyses were used to identify factors associated with diastolic dysfunction in axSpA. Results. A total of 357 axSpA patients were included in the analyses, of whom 78 (21.8%) exhibited diastolic dysfunction, with no reports of systolic dysfunction. Thirteen patients (3.6%) had valvular heart disease, and aortic valve regurgitation (n=5) and mitral valve regurgitation (n=6) were most common. Multivariable logistic regression analyses indicated that older age and higher body mass index (BMI) were positively associated with diastolic dysfunction, whereas human leukocyte antigen (HLA)-B27 positivity was negatively associated with diastolic dysfunction. Conclusion. Valvular heart disease is infrequent in Korean axSpA patients. However, diastolic dysfunction is common in axSpA patients, and is significantly associated with older age, higher BMI, and HLA-B27. (J Rheum Dis 2020;27:30-36)

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Objective. To systematically investigate the relationship between circulating interleukin-17 (IL-17) levels and systemic lupus erythematosus (SLE) and associations between polymorphisms in IL17 genes and SLE susceptibility. Methods. We performed a meta-analysis of serum/plasma IL-17 levels in patients with SLE and controls and evaluated the associations between the IL17A rs2275913, IL17F rs763780, and IL17F rs2397084 polymorphisms and IL17F copy number variations (CNVs) and risk of SLE. Results. Thirteen studies focusing on 2,096 patients with SLE and 2,587 controls were included. Our meta-analysis revealed that IL-17 levels were significantly higher in the SLE group than the control group (standardized mean difference=1.045, 95% confidence interval [95% CI]=0.521∼1.568, p<0.001). Subgroup analysis using sample size showed increased IL-17 levels in samples from large (n>100) but not small (n<90) SLE groups. We found no evidence of associations between SLE and the IL17A rs2275913, IL17F rs763780, and IL17F rs2397084 polymorphisms. However, a significant association was found between SLE and IL17F CNVs in a pooled cohort of affected individuals compared to that in pooled controls (odd ratio=3.663, 95% CI=2.466∼5.221, p<0.001). Conclusion. This meta-analysis revealed significantly higher circulating IL-17 levels in patients with SLE and showed evidence of associations between IL17F CNVs and SLE. (J Rheum Dis 2020;27:37-44)

6A Survey Study on Rheumatologist Consultation Time in Korean Hospitals

저자 : Hyun Ah Kim , Min Gwan Kim

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 45-50 (6 pages)

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Objective. In Korea, short physician consultation time has been a cause of concern as it compromises the care provided. This study was aimed at finding the actual and optimal consultation time per patient for rheumatology outpatient clinic in Korea. Methods. The surveys were prepared based on a study of the literature and consisted of multiple-choice questions as well as additional open questions. Surveys were conducted from November to February, 2018∼2019. Rheumatologist members of the Korean College of Rheumatology were invited to complete the web-based survey as well as paper survey. Results. The mean duration of consultation allocated to a new and an established patient was found to be 12.3 and 4.8 minutes, respectively, which corresponded to only 22%∼35.3% of perceived optimal consultation time. On the other hand, the intrusion of physician autonomy for optimal patient care by the hospital executive was manifest such that only 4.7% responded discretion in allocating consultation time for patients and that 61.3% replied that they have been restrained from keeping the adequate outpatient clinic volumes. Sixty six percent of respondents replied that insufficient consultation time affects patient safety including errors in prescription. Conclusion. Rheumatology consultation time is very insufficient compared to optimal situation. A drastic change in health care policy promoting good quality of care, such as appropriate compensation which guarantees sufficient consultation time, as well as strong policy to control excessive profit-driven management policy of the hospitals is urgently needed. (J Rheum Dis 2020;27:45-50)

7Clinical Usefulness of Uric Acid as a Biomarker for Knee Osteoarthritis: A Comparative Analysis With Plain Radiography and Musculoskeletal Ultrasound

저자 : Seong-kyu Kim , Ui Hong Jung , Jung-yoon Choe

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 51-60 (10 pages)

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Objective. The aim of this study was to determine the relationships of serum and urine uric acid with severity or activity in knee osteoarthritis (OA). Methods. A total of 42 patients with knee OA was enrolled, together with 58 healthy controls. Serum uric acid and spot urine uric acid levels were assessed for all patients. The severity and activity of knee OA were assessed by musculoskeletal ultrasound (MSUS) and plain radiography of the knee joint. Ultrasonographic abnormalities in knee OA includedsynovial hypertrophy, suprapatellar effusion, cartilage degradation, and osteophyte formation. Kellgren-Lawrence (K-L) grade was used to evaluate radiological progression of knee OA. Results. Patients with K-L grade III had a higher urine uric acid/creatinine ratio compared to those with K-L grade I (p=0.043). Patients with synovial hypertrophy had higher serum uric acid level compared to those without synovial hypertrophy (p=0.016). The urine uric acid/creatinine ratio was higher in patients with cartilage degradation compared to those without cartilage degradation (p=0.022). Serum uric acid was significantly associated with synovial hypertrophy thickness (r=0.375, p=0.018) but not with cartilage thickness after adjusting for age and body mass index. Lower urine uric acid was related with knee OA compared to healthy controls (odds ratio=0.974, 95% confidence interval 0.954∼0.994, p=0.013). Conclusion. The results of our study suggest that serum and urine uric acid reflects synovial inflammation based on MSUS and radiographic progression and then is associated with the pathogenesis of knee OA. (J Rheum Dis 2020;27:51-60)

8MicroRNA-10b Plays a Role in Bone Formation by Suppressing Interleukin-22 in Ankylosing Spondylitis

저자 : Pu-reum Park , Sungsin Jo , So-hee Jin , Tae-jong Kim

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 61-67 (7 pages)

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Objective. The microRNA (miR)-10b is the T helper (Th) 17 cell specific in patients with ankylosing spondylitis (AS). The interleukin (IL)-22, which is closely related to Th17 cells, has been implicated in the regulation of new bone formation in experimental models. Therefore, the aim of this study was to evaluate whether miR-10b affects bone formation via the IL-22 pathway in AS. Methods. Primary CD4+ T cells from AS were purified and transfected with miR-10b, anti-miR-10b, or scramble. Cell-surface markers and cytokine expression were analyzed by flow cytometry and enzyme-linked immunosorbent assay. Primary bone-derived cells (BdCs) from the facet joints of the spine were isolated, then osteogenic differentiation of primary BdCs was performed. We assessed alkaline phosphatase (ALP) activity and staining of BdCs at early time points. Alizarin red S staining of BdCs was performed at late time points. Results. Overexpression of miR-10b reduced both IL-22 producing cell frequencies and cytokine production in T cells from the patients with AS. The IL-22 significantly increased ALP staining and bone mineralization. The ALP promotor activity of AS-BdCs was notably higher for the IL-22 concentration. The supernatants of the miR-10b overexpression group suppressed ALP activity on osteogenic progenitor cells from the facet joints of the spine in patients with AS. Conclusion. Our data suggest that miR-10b suppresses IL-22 production, which was involved in osteogenic proliferation in AS. Therefore, miR-10b might be a potential therapeutic candidate for regulation of new bone formation in patients with AS. (J Rheum Dis 2020;27:61-67)

9Impending Cardiac Tamponade and Hemorrhagic Pleural Effusion as Initial Presentations of Incomplete Kawasaki Disease: A Case Report

저자 : Ye Ji Kim , Kyung Min Kim , Jae Young Lee , Ji Hong Yoon , Dae Chul Jeong , Woo Young Park , Gi Beom Kim

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 68-72 (5 pages)

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Kawasaki disease (KD) is an acute febrile illness that is characterized by systemic inflammation usually involving medium-sized arteries and multiple organs during the acute febrile phase, leading to associated clinical findings. The diagnosis is based on the principal clinical findings including fever, extremity changes, rash, conjunctivitis, oral changes, and cervical lymphadenopathy. However, KD diagnosis is sometimes overlooked or delayed because other systemic organ manifestations may predominate in acute phase of KD. As a cardiovascular manifestation, an acute pericarditis usually shows a small pericardial effusion, but large pericardial effusion showing clinical signs of cardiac tamponade is very rare. Here, we described a case of incomplete KD presenting with impending cardiac tamponade, and recurrent fever and pleural effusion. (J Rheum Dis 2020;27:68-72)

10A Case of Acute Lymphoblastic Leukemia Presenting as Unilateral Sternoclavicular Joint Arthritis and Mass

저자 : Eun-jung Park , Chang Lim Hyun , Jinseok Kim

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 1호 발행 연도 : 2020 페이지 : pp. 73-74 (2 pages)

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