논문 상세보기

KCI등재SCOUPUS

백신의 부작용

손영모
  • : 대한소아감염학회
  • : Pediatric Infection and Vaccine 3권2호
  • : 연속간행물
  • : 1996년 11월
  • : 117-122(6pages)

DOI


목차


					

키워드 보기


초록 보기


						

						

UCI(KEPA)

I410-ECN-0102-2017-510-000435405

간행물정보

  • : 의약학분야  > 소아과학
  • : KCI등재
  • : SCOPUS
  • : 연3회
  • : 2384-1079
  • :
  • : 학술지
  • : 연속간행물
  • : 1994-2020
  • : 731


저작권 안내

한국학술정보㈜의 모든 학술 자료는 각 학회 및 기관과 저작권 계약을 통해 제공하고 있습니다.

이에 본 자료를 상업적 이용, 무단 배포 등 불법적으로 이용할 시에는 저작권법 및 관계법령에 따른 책임을 질 수 있습니다.

발행기관 최신논문
| | | | 다운로드

1백신의 부작용

저자 : 손영모

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 117-122 (6 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

2초등학생의 베타용혈성 연쇄구균 보균자 검출에 있어서 인두부 중복배양(duplicate throat culture)의 유용성

저자 : 차성호 ( Sung Ho Cha ) , 한미영 ( Mi-young Han ) , 최용묵 ( Yong-mook Choi ) , 길영철 ( Young Chul Kil ) , 서진태 ( Jin-tae Suh )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 123-127 (5 pages)

다운로드

(기관인증 필요)

초록보기

Purpose : The most patients with acute streptococcal pharyngitis lack of classic clinical manifestations, therefore diagnostic laboratory test such as the throat culture or a rapid antigen detection test are frequently employed in primary practices of developed countries. We'd like to know the accuracy of the throat swab culture as gold standard for diagnosis of streptococcal infection with studying the discordant and concordant rate of duplicate culture. Methods : The study included 89 normal school children (boy:50, girl:39) who were attending U1jin primary school in U1jin, Kyong Sang Buk Do on March 1996. We obtained simultaneous 2 times of throat swab from each subject, and plating and streaking on 5-7% of sheep blood agar separately. We counted the characteristic beta-hemolytic colonies after overnight incubation. Results : 1) The carrier rate of beta-hemolytic streptococci at first culture is 25.1% and second one is 29.2%. 2) Ten out of 89(11.2%) is discordant in duplicate culture. 3) Culture containing less than 50 colonies of beta-hemolytic streptococci (+2) in first culture is 70.4%, second one is 85.7%. 4) Number of colonies is less than 50 in all ten discordant children. Conclusions : The discordant rate of duplicate throat swab culture for beta-hemolytic streptococci is 11.2%, even if the subjects are normal school children. About 5% of individuals harboring beta-hemolytic streptococci in the pharynx may be missed by a single throat culture. If we are trying to examine the patients with pharyngitis, the discordant rate will be much lower than this results.

3소아의 항결핵제 사용 실태

저자 : 김문희 ( Mun Hee Kim ) , 신영규 ( Young Kyoo Shin ) , 박상희 ( Sang Hee Park ) , 독고영창 ( Young Chang Tockgo )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 128-132 (5 pages)

다운로드

(기관인증 필요)

초록보기

Tuberculosis in children is an important disease because of higher incidence and mortality, especially in developing and underdeveloped countries. The objectives of this study were to evaluate the cause of antituberculosis medication in children and to find out the basic data for proper drug regimen. We reviewed the medical records of 198 patients who had been treated with anti- tuberculosis drug from Jan. 1991 to Dec. 1993 in Anam Hospital of Korea University Medical Center. The results are as following; 1) Of 198 patients, 69 cases(34.8%) had treated due to BCG complications. They were all medicated with INH. The durations of medication were 3 months in 46 patients(66.7%), 4~6 months in 17 patients(5.8%), 7~9 months in 4 patients(5.8%), 10-12 months in 2 patients(2.9%). 2) Of 198 patients, 68 cases(34.3%) had treated due to chemoprophylaxis, 59 patients (29.8% of all cases) had histories of house hold contact. Of 68 cases, 51 patients (86.4%) were medicated with INH only, 8 patients (13.6%) were medicated with INH and RFP. 3) Other causes of antituberculosis medication were tuberculous lymphadenitis(14.1%), pulmonary tuberculosis(10.6%), meningitis, military tuberculosis(2.0%), and pleurisy(2.0%). Most common causes of antituberculosis medications in children were complication of BCG vaccination and chemoprophylaxis after household contact. So early detection of adult tuberculosis and development of convenient diagnostic methods and safe vaccine for childhood tuberculosis is necessary.

4메티실린 내성 황색 포도상 구균에서 mecA, femA 유전자의 임상적 의의

저자 : 박정은 ( Jung-eun Park ) , 김택선 ( Taek-sun Kim ) , 박수성 ( Su-sung Park ) , 김은령 ( Eun-ryoung Kim ) , 김일수 ( Il-su Kim ) , 안일영 ( Il-young Ann ) , 김영진 ( Young-jin Kim ) , 짐재종 ( Jae-jong Kim ) , 강성옥 ( Sung-ok Kang ) , 박한오 ( Han-ho Park )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 133-138 (6 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

Purpose : In the treatment of MRSA infection, rapid detection of MRSA is extremely important. The mecA gene codes the new drug resistant polypeptides called PBP2' which mediates the clinically relevant resistance to all beta-lactam antibiotics. The identical mecA gene has been found in coagulase-negative staphylococcus with the methicillin-resistant phenotype. On the other hand, the femA gene was absent from coagulase negative staphylococcus strains with the methicillin resistant phenotype. This study is aimed at early detection and definite diagnosis of MRSA. Methods : A total of 24 MRSA strains were studied. All strains were tested for antimicrobial susceptibility and purified DNA. We amplified both mecA and femA genes by PCR in 24 strains. Results : In MRSA all the 16 strains (100%) carried femA gene and 11 strains (68.7%) carried mecA gene. In contrast, in methicillin sensitive staphylococcus all the 8 strains (100%) carried femA and only 3 strains (37.5%) were detected mecA. Conclusions : As results, there are difference in the phenotype and genotype of methi-cillin resistance by PCR of mecA and femA. Such disparities between methicillin resistance and the presence of mecA gene suggest the presence of control gene of the mecA.

5Coxiella burnetii감염과 가와사끼병과의 관련성에 관한 연구

저자 : 김종욱 ( Jong Wook Kim ) , 이해용 ( Hae Yong Lee ) , 이원영 ( Won Young Lee )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 139-144 (6 pages)

다운로드

(기관인증 필요)

초록보기

Purpose : Coxiella burnetii is a well-know causative agent of granuolmatous inflame-mation and an inducer of morphological change and transformation of human B lymphocyte in vitro. Coxiella burnetii manifests with several clinical symptoms depending upon the organs that are involved. We therefore undertook to clarify the association of Kawasaki disease and Coxiella burnetii. Subjects and Methods : The patient's sera were tested for antibodies specific for Coxiella burnetii, using indirect fluorescent antibody technique(IFA). We compared Coxiella burnetii infection with 3 groups of patients, group 1 (Kawasaki disease), group 2 (other febrile disease) and group 3 (control group). Results : 1) In children with Kawasaki disease (group 1), 93% of the patient tested positive for Coxiella burnetii. 2) In group 2 children, 20% of the patient tested positive for Coxiella burnetii. 3) In group 3 children, 10% of the patient tested positive for Coxiella burnetii 4) There were significant higher positive rate for Coxiella burnetii in Kawasaki disease than group 2 and group 3 (p<0.05). Conclusions : We concluded that our cases of Kawasaki disease were associated with Coxiella burnetii infection. Further studies will be needed to understand the precise role of Coxiella infection in Kawasaki disease.

61996년 초여름에 유행한 Adenovirus폐렴의 검토

저자 : 김창근 ( Chang Keun Kim ) , 정철영 ( Churl Young Chung ) , 김정숙 ( Jung Suk Kim ) , 이환종 ( Hoan Jong Lee )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 145-153 (9 pages)

다운로드

(기관인증 필요)

초록보기

The incidence of Adenovirus(AV) pneumonia in children is estimated as 8%. Long-term complications reported with type 7 include hyperleucent lung syndrome, bronchiolitis obliterans and may require several months to recover. We reviewed 8 case of AV pneumonia confirmed by AV culture and sero-diagnosis among selected 19 AV pneumonia suspicious cases who were admitted to the Sanggye Paik Hospital of Inje University due to clinical pneumonia from May to July 1996. From 19 children, nasal aspirates or trachial aspirates were collected: viral agents were detected by virus isolation and virus antigen was detected by indirect immunofluorescent staining. Serologic diagnosis for type-specific AV antibody was done by neutralization test. The results are as follows : 1) Age of the patients ranged from 6 months to 47 months with a mean of 24±9 months. 6 were male and 2 were female(M:F= 3:1). 2) Monthly distribution showed 4 cases on June, 2 cases on May and July, respectively. 3) The mean duration of admission was 20.4 days and mean duration of fever was 11.3 days 4) Peripheral leukocyte counts were elevated in 4 cases(50%) and findings of shift to left were showed in 4 cases(50%) and serum aminotransferase activities were elevated in 6 cases(75%). 5) Radiologic findings include linear and streaky infiltration(1/8 cases), patchy and lobar consolidation (7/8 cases), pleural effusion(2/8 cases) and hyperleucency was seen in 3/8 cases at time of admission and increased to 6/8 cases on hospital discharge. 6) The AV serotypes were type 7, type 3, and type 1. 7) Oxygen supply was done in 4 cases(50%) and all 8 patients include 2 cases of type 7 treated with artificial ventilator were survived. In conclusion, the serotypes of AV pneumonia outbreaks in early summer of 1996 were type 7, 3, 1 and, as showed severe clinical course, continued follow up surveillance is necessary to the long term pulmonary complications.

7아데노바이러스에 의한 소아 하기도 감염에 대한 임상적 고찰

저자 : 손진아 ( Jin-a Son ) , 이상일 ( Sang-il Lee ) , 이남용 ( Nam-young Lee ) , 김정희 ( Jung-hee Kim )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 154-162 (9 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

Purpose : Adenoviruses(Ad) have been shown to play an important role in the etiology of severely acute respiratory diseases, particulary in infants and young children, and the occurrence of fatal outcome and chronic pulmonary sequelae in association with adenoviral infection has been a cause of great interest and concern. This report presents the resul of a retrospective analysis on 30 cases of lower respiratory infection from which adenovirus was isolated. Patients & Methods : The 30 patients in this study represent all detected cases of adenovial infection out of 240 children who were admitted to Sang Sung Medical Center between February to June 1996 showing signs and symptoms of lower respiratory tract infection. The diagnosis of adenovirus infection was based on microscopic visualization of typical cytopathic effect in HEp-2 tissue culture and used monoclonal Ab with naso-pharyngeal aspiration. Results : The male/female ratio was 2:1 and the majority of age range was below 36months. Clinical diagnoses in all 30 patients were pneumonia(n=21), bronchitis and Bronchiolitis(n=5) and ARDS(n=4). We recieved the most of patients in the month of May. The chief complaints were fever(93.3%) and cough(80%) and extrapulmonary symptoms were diarrhea(n=5), seizure(n=4), abdominal pain(n=1). The mean duration of fever was 11.95±6.54days. Physical examination on admission were crackles(73.3%), coarse breathing sounds(60%), hepatosplenomegaly(33.3%), decreased brething sounds(30%). In WBC counts, 8cases were below 4000/mm3 and 14 cases were above 10,000/mm3. In platelets counts, 4cases were below 150,000/mm3 and 10 cases were above 450,000/mm3. 21 cases were above 1 in CRP. GOT and GPT were abnormal in some cases. Chest X-ray revealed diffuse pulmonary infiltration(n=15), pleural effusion(n=6), consolidation(n=4) and hyper-aeration(n=3). Seven patients were treated at the peditric intensive care unit with respiratory support and high dose of gammaglobulin. However, one patients died even through he was treated with NO ventilation and high frequency ventilation. Conclusion : Those with adenoviral pneumonia and respiratory infection having long fever duration and symptoms like bacterial pneumonia must be carefully differentiated in order to provide proper treatement and preventive measures due to possible fatal outcome.

8무균성 수막염 환자의 뇌척수액 채취 시기와 장바이러스 RNA 검출과의 관계

저자 : 이규만 ( Kys Man Lee ) , 박순영 ( Soon Young Park ) , 강희정 ( Hee Jung Kang ) , 이은희 ( Eun Hee Lee )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 163-167 (5 pages)

다운로드

(기관인증 필요)

초록보기

Aseptic meningitis, the most common infection of the central nervous system, is an acute illness mostly caused by enteroviruses. Cerebrospinal fluid(CSF) has been used for the detection of enteroviral RNA but the detection has been mostly performed in a single CSF specimen obtained during the illness. A major objective was to evaluate the relation of sampling time to the recovery of enteroviral RNA in CSF. Thirty seven CSF specimens were obtained from 24 patients between May and August 1993, when an outbreak of asceptic meningitis by echovirus type 9 occured. Enteroviral RNA in CSF was detected by polymerase chain reaction(PCR). Data about onset of symptom development were obtained by review of medical records. Enteroviral RNA was detected by PCR in 29 of 37 CSF specimens. PCR yielded positive results in 4 of 5 CSF specimens obtained on day 1 to 3, 10 of 11 on day 4 to 6, 8 of 10 on day 7 to 9, 6 of 8 on day 10 to 12, 1 of 3 on day 13 to 15 postonset. Of 11 patients from each of whom more than one CSF were obtained on different day postonset, PCR yielded positive results in 2 of 3 cases in whom enteroviral RNA detection was negative in the first CSF. These result indicate that two or more CSF specimens obtained within 12 days postonset are required for improving the accuracy of the diagnosis of enteroviral meningitis.

9무균성 뇌막염에서 증상발현부터 진단까지 걸린 시간에 따른 시기별 유병기간의 검토

저자 : 김탁수 ( Tag Soo Kim ) , 허지연 ( Ji Yeon Hur ) , 박영희 ( Young Hee Park ) , 정민구 ( Min Goo Jung ) , 김성원 ( Sung Won Kim )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 168-174 (7 pages)

다운로드

(기관인증 필요)

초록보기

Purpose : Aseptic meningitis is relatively frequent in children and caused mostly by enterovirus. The aim of the present study was to determine the effect of early diagnosis (spinal tapping) on symptom duration of childhood aseptic meningitis. Methods : One hundred fifty-three children who were hospitalized due to aseptic menigitis in the Department of pediatrics St. Benedict Hospital from July 1996 through October 1996 were included in this study. Patients were divided to two groups according to the duration from first symptom onset to diagnosis. Early diagnosis group is diagnosed within 3 days from first symptom onset. Later diagnosis group is diagnosed after 4 days from first symptom onset. Results : 1) The average age of these patients was 4.3 years old in early diagnosis group and 4.1 years old in later diagnosis group. The sex ration(male: female) was 2.04:1 in early diagnosis group and 2.5:1 in later diagnosis group. 2) The mean duration of diagnosis of this study was 2.04 day in early diagnosis group and 5.12 day in later diagnosis group. 3) The percentage of symptom and sign of the early diagnosis group were fever(100%), headache(88.4%), vomiting(86.9%), abdominal pain(39%), neck stiffness(36.2%), skin rash (18.8%), diarrhea(16.9%) and that of later diagnosis group were fever(100%), headache(83.3), vomiting(80.9%), abdominal pain(47.6%), neck stiffness(41.6%), skin rash(29.7%), diarrhea(16.6%). 4) Initial CSF findings revealed leukocyte 146.8±386.3/mm3 with PMNL 38%, protein 32.47mg/dl, sugar 66.23mg/dl in early diagnosis group and leukocyte 458.1±663.2/mm3, protein 31.22mg/dl, sugar 64.21 mg/dl in later diagnosis group. 5) There was no statistically significant difference in the peripheral blood findings between early diagnosis group and later diagnosis group. 6) The duration of disappearance of symptom after spinal tap were 2.3 days in early diagnosis group and 2.24 days in later diagnosis group. Total symptom duration was 4.34 days in early diagnosis group and 7.36 days in later diagnosis group. Conclusions : Our results demonstrate that early diagnosis(early spinal tap) shortened duration of clinical symptoms.

10소아의 연령증가에 따른 볼거리 및 풍진 항체

저자 : 전혜원 ( Heaewon Cheon ) , 신영규 ( Kangwoo Lee ) , 이강우 ( Youngkyoo Lee ) , 정지태 ( Jitae Chung ) , 독고영창 ( Youngchang Tockgo )

발행기관 : 대한소아감염학회 간행물 : Pediatric Infection and Vaccine 3권 2호 발행 연도 : 1996 페이지 : pp. 175-184 (10 pages)

다운로드

(기관인증 필요)

초록보기

Purpose : This study was intended to measure seropositivities and the levels of mumps-and rubella-specific IgG of MMR vaccines over 17 months of age in Korea. Materials and Methods : From June 1994 to April 1995 we obtained sera from visitors of well baby clinic and patients in Korea University Hospital, who were MMR vaccinees over 17 months of age and had no evidence of immunodeficiency. These 275 study population include 145 males and 130 females. Mumps- and rubella-specific IgG antibody levels were measured by ELISA. Cut-off values for seropositivity were 20 GU(Gamma Unit) in mumps and 0.17 in rubella. Results : 1) As age increased, seropositivities of mumps-specific IgG increased significantly, being 69.0% in 1.5~2 year, 75.0% in 3~4 year, 76.0% in 5~6 year, 90.0% in 7 year, 100% in 8 year, 96.9% in 9 year, 97.4% in 10 year, 97.4% in 11 year, and 96.6% in 12 year of age (p<0.001). 2) As age increased, the levels of mumps-specific IgG antibody(mean±standard deviation, GU) increased significantly, being 64.9±66.5 in 1.5-2 year, 117.7±126.4 in 3~4 year, 152.3±147.1 in 5~6 year, 194.3±168.2 in 7 year, 258.1±190.6 in 8 year, 193.1±130.1 in 9 year, 225.7±119.6 in 10 year, 220.7±114.3 in 11 year, and 222.3±127.1 in 12 year of age(p<0.001). There was positive correlation between age and mumps-specific antibody level (r=0.3282, p<0.001). 3) As age increased, seropositivities of rubella-specific IgG decreased significantly, being 72.4% in 1.5~2 year, 75% in 3~4 year, 72% in 5~6 year, 60% in 7 year, 44.4% in 8 year, 40.6% in 9 year, 28.2% in 10 year, 23.1% in 11 year, and 17.2% in 12 year of age(p<0.001). 4) As age increased, rubella-specific IgG decreased significantly, being 0.462±0.356 in 1.5~2year, 0.438±0.306 in 3~4 year, 0.287±0.179 in 5~6 year, 0.204±0.139 in 7 year, 0.189±0.153 in 8 year, 0.124±0.121 in 9 year, 0.093±0.114 in 10 year, 0.104±0.135 in 11 year, and 0.080±0.001 in 12 year of age(p<0.001). There was negative correlation between age and rubella-specific IgG titer (r=-0.551, p<0.001). Conclusions : Eventhough seropositivities and the level of mumps-specific IgG increased as age increased, they are not enough to prevent mumps infection in 1.5 to 6 years of age. Seropositivities and the level of rubella-specific IgG decreased as age increased. Appropriate change in vaccine schedule may be needed to decrease the risks of mumps and rubella infection.

12
주제별 간행물
간행물명 수록권호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
27권 2호 ~ 27권 2호

KCI후보

대한췌담도학회지
25권 2호 ~ 25권 2호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
27권 1호 ~ 27권 1호

KCI후보

대한췌담도학회지
25권 1호 ~ 25권 1호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
26권 3호 ~ 26권 3호

KCI후보

대한췌담도학회지
24권 4호 ~ 24권 4호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
26권 2호 ~ 26권 2호

KCI후보

대한췌담도학회지
24권 3호 ~ 24권 3호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
26권 1호 ~ 26권 1호

KCI후보

대한췌담도학회지
24권 2호 ~ 24권 2호

KCI후보

대한췌담도학회지
24권 1호 ~ 24권 1호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
25권 3호 ~ 25권 3호

KCI후보

대한췌담도학회지
23권 4호 ~ 23권 4호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
25권 2호 ~ 25권 2호

KCI후보

대한췌담도학회지
23권 3호 ~ 23권 3호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
25권 1호 ~ 25권 1호

KCI후보

대한췌담도학회지
23권 2호 ~ 23권 2호

KCI후보

대한췌담도학회지
23권 1호 ~ 23권 1호

KCI등재 SCOUPUS

Pediatric Infection and Vaccine
24권 3호 ~ 24권 3호

KCI후보

대한췌담도학회지
22권 4호 ~ 22권 4호
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기