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대한본초학회> 대한본초학회지(본초분과학회지)

대한본초학회지(본초분과학회지) update

The Korea Jounrnal of Herbology

  • : 대한본초학회
  • : 의약학분야  >  기초한의학
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  • : 1229-1765
  • : 2288-7199
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수록정보
수록범위 : 1권0호(1986)~35권2호(2020) |수록논문 수 : 1,585
대한본초학회지(본초분과학회지)
35권2호(2020년 03월) 수록논문
최근 권호 논문
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KCI등재

1Urushiol의 화학적 변화를 통한 건칠(乾漆)의 포제법(炮製法) 고찰

저자 : 김정훈 ( Jung-hoon Kim ) , 도의정 ( Eui Jeong Doh ) , 이금산 ( Guemsan Lee )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 2호 발행 연도 : 2020 페이지 : pp. 1-6 (6 pages)

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Objectives : Heating process is the traditional processing method that has been applied to reduce the toxicity of dried resin of Toxicodendron vernicifluum (Anacardiacea) used as Geon-chil (乾漆, Lacca Rhois Exsiccata or Toxicodendri Resina). Urushiol, which is found in the plants of Toxicodendron genus, is a toxic compound that is absorbed into the skin and induces allergic dermatitis by being contacted. Hence, the reduction of urushiol level by heating processing of Geon-chil is crucial method for its medicinal application.
Methods : Due to lack of Geon-chil processing-related articles, the articles researching the processing of lacquer (漆), as a coating material, were collected and analyzed to investigate the chemical change of urushiol during heating process.
Results : The results demonstrate that the resin which was collected from the sap of T. vernicifluum tree was dried under warm and humid conditions repeatedly. During primary drying process, the laccase, a copper-containing enzyme in the resin, participated in the formation of urushiol polymers and thereafter urushiol-related toxicity could be reduced by making a lacquer harder and more stable. Moreover, heating a lacquer over 200℃ could cause thermodegradation of urushiol polymers, and vaporized thermally degraded urushiol monomers and their by-products, which were determined using pyrolysis/GC-MS.
Conclusions : These results support that heating process being performed over 200 ℃, such as stir-frying (炒) or calcination (煅), reduces the urushiol content in Geon-chil and hence, its medicinal use can be more stable without urushiol-related allergic reactions.

KCI등재

2소화기 질환 동물모델에서 평위산(平胃散)의 염증 완화 효과

저자 : 정세영 ( Seyoung Jung ) , 정성은 ( Sung Eun Jung ) , 김지혜 ( Ji Hye Kim ) , 함성호 ( Seong Ho Ham ) , 양웅모 ( Woong Mo Yang ) , 권보인 ( Bo-in Kwon )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 2호 발행 연도 : 2020 페이지 : pp. 7-14 (8 pages)

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Objectives : Pyeongwi-san is widely used in Korean medicine for acute indigestion or gastrodynia. As a therapeutic agent for digestive diseases of modern people, in order to confirm the mechanism of Pyeongwi-san on digestive tract disease and the difference of therapeutic efficacy between its formulation, a comparative efficacy test was conducted on digestive tract disease animal model.
Methods : For LPS enteritis animal model, male SD rats were intraorally treated with different formulation types of Pyeongwi-san, and then intraperitoneally administered LPS one hour later to induce enteritis. After 5 hours, blood was collected and TNFα, IL-1β, IL-6 and PGE2 were confirmed by ELISA. For acute gastritis animal model, male SD rats were intraorally treated with different formulation types of Pyeongwi-san according to the prescribed concentration, and then intraorally administered 60% ethanol and 150 mM HCl one hour later to induce acute gastritis. After 5 hours, blood was collected and TNFα ,IL-6 were confirmed by ELISA.
Results : In the LPS-administered enteritis animal model, Pyeongwi-san decreased TNFα, IL-1β, PGE2 and especially IL-6. Pyeongwi-san also decreased IL-6 in acute gastritis animal model. In addition, there was no significant difference in efficacy between the two formulations when compared with inflammatory markers.
Conclusions : The efficacy of Pyeongwi-san was confirmed in the inflammatory markers related to digestive inflammatory diseases, and the efficay between two formulations of Pyeongwi-san was relatively similar. Further studies are needed to investigate the new applicability of Pyeongwi-san on different inflammatory diseases that have similar inflammation markers identified in this experiment.

KCI등재

3천속단(川續斷)과 한속단(韓續斷)의 기원에 관한 문헌 고찰

저자 : 신상문 ( Sangmun Shin ) , 도의정 ( Eui-jeong Doh ) , 송호준 ( Ho-joon Song ) , 박성주 ( Sung-joo Park ) , 이금산 ( Guemsan Lee )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 2호 발행 연도 : 2020 페이지 : pp. 15-29 (15 pages)

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Objectives : This study aimed to review the change in the origin of Sokdan(續斷) by diachronically analyzing literature data from Korea and China.
Methods : Literature records describing the origin(synonyms, location of production, description) of Sokdan were collected, records were divided into periods. The main contents were included in the results, and original texts were edited and summarized in the table.
Results : Sokdan, whose leaves resemble Jeoma(苧麻)(SJ), was first recorded in 《Xinxiubencao(新修本草)》, and described in detail in 《Bencaotujing(本草圖經)》 during the Tang and Song dynasties in China. In modern times, SJ was assumed to be genus Phlomoides or Lamium; however, records of the plant have decreased. Finally, SJ was not included in the 《Pharmacopoeia of the People's Republic of China》 as Sokdan. However, 《Diannanbencao(滇南本草)》, 《Diannanbencaotushuo (滇南本草圖說)》, 《Zhiwumingshitukao(植物名實圖考)》 described Sokdan of dian(滇). It was assumed genus Dipsacus . From the 1950s onwards, Sokdan is described in the literature as a member of the genus Dipsacus. In korea, SJ was recorded in 《Hyangyakjipseongbang(鄕藥集成方)》 and 《Dongeuibogam(東醫寶鑑)》 during the Joseon dynasty. In modern times, the genera Phlomoides and Lamium were mostly recorded as the origin of Sokdan.
Conclusions : Several species have been described as Sokdan over the years in China, but since the 1950s, the genus Dipsacus was noted as the origin of Sokdan. In Korea, SJ was used in the past, thus Sokdan was recorded as P. umbrosa in 《The Korean Herbal Pharmacopoeia(KHP)ㆍ1985》. However, 《KHPㆍ1998》 referred to P. umbrosa as Hansokdan and D. asperoides as Sokdan.

KCI등재

4작약감초탕의 추출용매에 따른 성분 분석 및 항피로 효능 비교

저자 : 성윤영 ( Yoon-young Sung ) , 육흥주 ( Heung Joo Yuk ) , 김동선 ( Dong-seon Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 2호 발행 연도 : 2020 페이지 : pp. 31-38 (8 pages)

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Objectives : Jakyakgamcho-tang has been used as analgesic and spasmolytic for muscle pain. It has reported to anti-diabetes, anti-inflammation, and neuro-protective effects. A clinical study of muscle fatigue and pain improvement effect of Jakyakgamcho-tang has been reported with increasing frequency of clinical use. However, the anti-fatigue effect of Jakyakgamcho-tang in animal model has not been studied. In this study, we compared anti-physical fatigue effects of water and 30% ethanol extract of Jakyakgamcho-tang.
Methods : The amounts of components contained in water and 30% ethanol extract of Jakyakgamcho-tang were compared by ultra-performance liquid chromatography. Anti-physical fatigue effects were evaluated using weight-loaded forced swimming test. We also investigated the effects of Jakyakgamcho-tang on the change of fatigue parameters by blood biochemical analysis.
Results : The relative amount of components of Jakyakgamcho-tang were about 19-53% higher in the 30% ethanol extract than in the water extract. In the swimming test, 30% ethanol extract showed a significantly greater anti-fatigue effects than conventional water extract of Jakyakgamcho-tang. The 30% ethanol extract of Jakyakgamcho-tang improved the exhausted swimming time (54%), and serum lactate dehydrogenase (48%) and lactic acid (60%) levels compared with water extract of Jakyakgamcho-tang.
Conclusions : These results showed that differences in the amounts of components by different extraction were associated with differences of anti-fatigue effect of Jakyakgamcho-tang. Thus, the 30% ethanol extraction method could be applied to dose-reducing formulations of traditional herbal medicines.1)

KCI등재

5곤충 유래 한약재를 활용한 피부질환 개선 기능성 소재에 대한 특허 동향 분석

저자 : 이지혜 ( Ji Hye Lee ) , 문병철 ( Byeong Cheol Moon ) , 남현화 ( Hyeon Hwa Nam ) , 김중선 ( Joong Sun Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 2호 발행 연도 : 2020 페이지 : pp. 39-46 (8 pages)

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Objective: In this study, we analyzed the trend of patents registered prior to October 4, 2019, to understand the industrial trends in insect-derived medicinal materials used for the treatment of skin diseases.
Methods: Using the WIPSON database, we collected information regarding the patents related to insect-derived materials for treating various skin diseases.
Results: The patents registered prior to October 4, 2019, from Korea, Japan, the USA, China, and the EU, along with those registered under PCT were selected. There were 195 patents related to the use of insect-derived medicinal materials in treating various skin diseases such as psoriasis, inflammatory skin diseases, eczema, pruritus, and atopic dermatitis. China is mostly superior in total number of registered patents compared with the other countries. Korea was the major patent technology-holder for atopic dermatitis, but China dominated in the remaining categories of skin diseases. Upon first patent registration in 1992, there had been a continual increase in the number of patents. Especially, patents related to eczema, psoriasis, inflammatory skin disease were markedly increased. Most frequently used insect-derived medicinal materials was Scolopendra, Cicadidae Periostracum, Scorpions, Cantharides, and Batryticatus Bombyx. The insect-derived medicinal materials were generally used as a combined preparation with other medicinal materials in patents.
Conclusion: This study could help to establish the basis for future research and development related treating skin diseases using insect-derived medicinal materials. In order to provide sufficient data, further study including analysis of rejected patents is needed.

KCI등재

6백강잠 추출물의 C57BL/6 마우스를 이용한 2주경구투여 독성시험

저자 : 남현화 ( Hyeon-hwa Nam ) , 서윤수 ( Yun-soo Seo ) , 문병철 ( Byeong-cheol Moon ) , 이지혜 ( Ji-hye Lee ) , 김용범 ( Yong-bum Kim ) , 김중선 ( Joong-sun Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 2호 발행 연도 : 2020 페이지 : pp. 47-53 (7 pages)

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Objectives : Bombyx batryticatus L. is the dried larval form of the silkworm (Bombyx mori L.) infected by Beauveria bassiania (Bals.) Vuill. It is used as a food and medicinal resource to treat asthma, headaches, epilepsy, and convulsions in traditional Korean and Chinese medicines. However, the research of the toxicity about B. batryticatus is not enough yet. Here, we investigate the effects of potential subacute toxicity following the repeated oral administration of B. batryticatus water extract to C57BL/6 mice, at various doses of 0, 50, 150, and 450 ㎎/㎏/day during a two-week period.
Methods : The following parameters were examined during the study period: body weight, gross findings, clinical signs, organ weight, hematology, serum biochemistry, histopathology, and mortality. At the end of the treatment period, all the mice were euthanized.
Results : No changes were observed in the body weights, gross findings, clinical signs, organ weights, and mortality after two weeks of administration of the B. batryticatus extract. In addition, compared with the normal control group, no noticeable treatment-related changes were observed in the hematological, serum biochemical, and histopathological parameters in the treated group following treatment with doses of up to 450 ㎎/㎏/day.
Conclusion : Based on these findings, we conclude that the treatment of mice with the water extract of B. batryticatus did not cause considerable C57BL/6 toxicity, and therefore, it could be considered safe for further pharmacological studies.1)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동41회 피인용

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