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Allergy asthma & respiratory disease update

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수록정보
수록범위 : 1권1호(2013)~5권5호(2017) |수록논문 수 : 348
Allergy asthma & respiratory disease
5권5호(2017년 09월) 수록논문
최근 권호 논문
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KCI등재

1식품알레르기의 자연경과에 영향을 주는 요인

저자 : 이소연 ( So-yeon Lee )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 237-238 (2 pages)

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2약물알레르기 검사의 시행과 해석: 전문가 의견서

저자 : 양민석 ( Min-suk Yang ) , 반가영 ( Ga-young Ban ) , 김민혜 ( Min-hye Kim ) , 임경환 ( Kyung-

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 239-251 (13 pages)

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Diagnostic methods for drug allergy include the patient's history, in vivo skin test, in vitro laboratory test, and provocation test. How-ever, the history is often not reliable, procedures for in vivo and in vitro tests are not standardized, and provocation tests are some-times harmful to patients. Generally, skin prick and intradermal tests are useful for immediate reactions; in contrast, patch test and delayed reading of both skin prick and intradermal tests are helpful for delayed reactions. A drug provocation test is the gold stan-dard for both responses, and it is necessary to be aware of exact indications and contraindications with appropriate drugs, doses, and intervals. To date, several methods have been developed to detect culprit agents for drug hypersensitivity reactions, but they are neither completely well validated nor standardized. Based on this awareness and necessity, the Korean Academy of Asthma, Al-lergy and Clinical Immunology launched the Standardization Committee to review the international guidelines and the literature, and then developed the consensus report on the procedures and applications of diagnostic tests for drug allergy. (Allergy Asthma Respir Dis 2017;5:239-247)

KCI등재

3알레르기 염증에서의 비만세포 역할과 비만세포 관련 질환

저자 : 김희규 ( Hee-kyoo Kim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 248-255 (8 pages)

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Mast cells, which are major effector cells in allergic reactions, are found in the perivascular spaces of most tissues and contain pro-in-flammatory and vasoactive mediators. These mediators are released after IgE receptor cross-linking induced by allergens or other stimuli, including anaphylatoxins (C3a and C5a), aggregated IgG, certain drugs, venoms, and physical stimuli (pressure and tempera-ture changes), as well as cytokines and neuropeptides. The excess release of these mediators can cause variable allergic symptoms and signs, such as bronchospasm, itching, flushing, nausea, vomiting, diarrhea, abdominal pain, vascular instability, and anaphylaxis. Furthermore, mast cell disorders may involve either excessive proliferation of mast cells or abnormal mast cell reactivity. Mast cell disorders can be broadly divided into 3 types: primary, secondary, and idiopathic. All of these disorders present with signs and symp-toms of mast cell activation and differ in severity and involvement of various organ systems. The best characterized primary disorder is mastocytosis. Systemic and cutaneous forms of the disease are well described. Secondary disorders include typical allergic dis-eases and some types of urticarial diseases. In this article, the biochemical characteristics of mast cells and the role of mast cells in al-lergic inflammation, as well as the classification, diagnosis, and management of mast cell-related disorders, will be reviewed. (Allergy Asthma Respir Dis 2017;5:248-255)

KCI등재

4아토피피부염이 영유아의 식품알레르기 자연경과에 미치는 영향

저자 : 박지선 ( Ji Sun Park ) , 문순정 ( Soon Jeong Moon ) , 임대현 ( Dae Hyun Lim ) , 장해지 ( Hae

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 256-261 (6 pages)

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Purpose: There have been studies showing that food allergy plays a role in the pathogenesis of atopic dermatitis. However, there have been few studies about the effect of atopic dermatitis on remission of food allergy. Thus, this study aimed to evaluate the dif-ference in remission according to the presence of atopic dermatitis in infants and young children with milk or egg allergy. Methods: A retrospective study was performed on 109 infants and young children with IgE-mediated food allergy in a tertiary hos-pital. They divided into food allergy with atopic dermatitis (FA with AD) and without atopic dermatitis (FA without AD). Results: In the milk allergy group, initial milk-specific IgE levels were 21.16±27.98 kUA/L and 11.36±22.88 kUA/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of milk allergy at 36 months of age were 64.9% and 90.0%, respectively, in FA with AD and FA without AD. In the egg allergy groups, initial egg-specific IgE levels were 34.48±36.72 kUA/L and 15.66±28.60 kUA/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of egg allergy at 36 months of age were 61.2% and 90.0% in children with FA with AD and FA without AD. Conclusion: Atopic dermatitis may play an important role in the natural history of food allergy in infants. Different strategies are needed for the management of food allergy in young children with atopic dermatitis. (Allergy Asthma Respir Dis 2017;5:256-261)

KCI등재

5임상적 천식 소아에서 기관지유발시험 중 관찰되는 두 호흡곤란 지표의 특성 비교

저자 : 김유선 ( You Sun Kim ) , 신정민 ( Jeongmin Shin ) , 최윤정 ( Yun Jung Choi ) , 송준혁 ( Jun-

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 262-268 (7 pages)

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Purpose: Dyspnea is the cardinal symptom of asthma, but it is difficult to quantify clinically. Although modified Borg (mBorg) scale has been successfully used in adult, but there has been some difficulties to apply in children. Recently, Pediatric Dyspnea Scale (PDS) was adequately designed and has been widely used. The aim of this study is to compare 2 evaluating scales of dyspnea provoked by induced-bronchoconstriction in childhood asthma. Methods: Seventy-three clinically suspected children with asthma were enrolled in this study. Each 'fractional exhaled nitric oxide (FeNO)' was documented. Forced expiratory volume in 1 second (FEV1), mBorg score and PDS score were recorded during metha-choline provocation test. Results: Mapping using canonical plot demonstrated global similarity between 2 scales with some distinctive features. Whereas mBorg score showed more diverse categories in low level of dyspnea, PDS score did in medium level of it. A distribution of dyspnea perception score at a 20% decrease in FEV1 relative to baseline (PS20), a perception score of dyspnea at 20% fall in FEV1 of 2 scales represented similar wide, biphasic feature. Statistical relevance was verified with spearman correlation (Rs=0.903, P<0.001) and Bland-Altman analysis. PS20 of both scores and FeNO had no statistical relationship. While relationship between PS20 by mBorg score and the concentration of methacholine at 20% fall in FEV1 (PC20) was not significant (Rs=0.224, P=0.154), that between PS20 by PDS and PC20 was weak positive (Rs=0.29, P=0.063). Conclusion: PDS had similar pattern to assess the dyspnea with the mBorg scale suggesting adequacy of PDS in evaluating pediat-ric clinical asthma. We expect these scales to help clinical practice in complementary ways. (Allergy Asthma Respir Dis 2017;5:262-268)

KCI등재

6소아에서 human metapneumovirus 감염의 최근 역학 및 임상 양상: 2011-2014

저자 : 장명선 ( Myeong Sun Jang ) , 신미용 ( Meeyong Shin )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 269-273 (5 pages)

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Purpose: This study was performed to investigate the epidemiologic and clinical features of human metapneumovirus (hMPV). Methods: We performed real-time reverse transcription polymerase chain reaction with nasopharyngeal samples from 2,403 chil-dren who were hospitalized with acute respiratory infection. Then medical records of 120 children, who were diagnosed with hMPV respiratory infection between 2011 and 2014, were retrospectively analyzed retrospectively and compared to epidemiologic data on respiratory virus infection reported by Korea Centers for Disease Control and Prevention. Results: We detected 120 hMPV-positive cases out of 1,723 virus-positive specimens (7.0%), which prevailed mostly in spring be-tween March and May. Respiratory infection with hMPV was more common in female patients (55.0%) and hPMV infection was prevalent among children aged <5 years (80.8%). Coinfections with other respiratory viruses were observed in 34 patients of 120 hMPV-positive cases (28.3%), mostly with rhinovirus (52.9%). In addition, hPMV infection mostly presented with pneumonia (71.7%). Among 120 hMPV-positive patients during the recent 4 years, most (68.3%) were diagnosed in 2014. During 2011-2014, influenza virus infection was prevalent mainly from January to March, and hMPV infection started to appear just after the end of influenza vi-rus outbreak. Conclusion: In Korean children, hMPV was a common causative organism of viral pneumonia during the spring season. The hMPV infection pandemic was observed in 2014 and the clinical importance of hMPV has recently been increasing. Therefore, additional studies are required to define the epidemiology, disease characteristics caused by hMPV, and the cause of recent outbreak. (Allergy Asthma Respir Dis 2017;5:269-273)

KCI등재

7후두기관지폐렴으로 진단된 소아 환자들의 임상 양상과 원인: 크룹 환아와의 비교

저자 : 김은진 ( Eun Jin Kim ) , 남혜나 ( Hyena Nam ) , 선용한 ( Yong Han Sun ) , 차한 ( Hann Tchah

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 274-279 (6 pages)

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Purpose: Croup, a common childhood respiratory illness with various severities, has many unanswered questions. Laryngotracheo-bronchopneumonitis (LTBP) is a disease entity considered to be an extension of croup to the lower respiratory tract. The object of this study was to compare epidemiology, clinical characteristics, and viral etiologic spectrum between croup and LTBP. Methods: Patients hospitalized with croup at Gachon University Gil Hospital from January 2010 to April 2016 were recruited. LTBP was defined as pneumonia confirmed on radiographs of patients with croup. Clinical findings and demographic data were re-viewed of patients whose nasopharyngeal swabs were done for viral analysis. Results: A total of 371 patients with only croup and 63 patients with LTBP were included. Croup was found to be significantly associ-ated with parainfluenza virus type 1 (P=0.006). LTBP was related to parainfluenza virus type 3, respiratory syncytial virus, and hu-man bocavirus (P=0.001, P=0.030, and P=0.019, respectively). The duration of fever was longer in patients with LTBP than in those with croup (3.87±1.85 days vs. 2.86±1.80 days, P<0.001). Conclusion: Specific etiologic viruses might be associated with the progression from croup to LTBP. Pronged fever is also associated with progression from croup to LTBP. (Allergy Asthma Respir Dis 2017;5:274-279)

KCI등재

8마이코플라스마 폐렴에서 조기 스테로이드 사용의 유용성

저자 : 김희성 ( Hee Seong Kim ) , 송명곤 ( Myung Gon Song ) , 김용욱 ( Yong Wook Kim ) , 김경심 ( K

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 280-286 (7 pages)

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Purpose: The aim of this study was to evaluate whether or not the early use of steroid is useful for treating Mycoplasma pneumoniae pneumonia. Methods: A prospective study was conducted on 85 patients with M. pneumoniae pneumonia admitted to Gwangju Christian Hos-pital between September 2015 and April 2016. A total of 85 patients were enrolled. Of these, 33 were treated with steroids (methyl-prednisolone 1 mg/kg/day), while 52 were not; both were treated with macrolides. The overall duration of fever was compared be-tween the 2 groups and findings on chest radiographs were evaluated for their deterioration. Results: The duration of fever after admission (1.36±0.92 days vs. 2.17±1.30 days, P=0.003) and the overall duration of fever (4.42±2.13 days vs. 6.07±2.59 days, P=0.003) were significantly lower in the steroid group. The duration of fever before admission was not different between the steroid and macrolide groups (3.06±1.74 days vs. 3.90±2.21 days, P=0.068). On chest radiographs taken 3 days later, 1 of 33 patients in the steroid group and 5 of 50 patients in the macrolide group worsened, although there was no statistically significant difference between the 2 groups (P=0.395). There was no significant difference in the duration of hospi-talization between the 2 groups (6.72±1.54 days vs. 6.92±1.87 days, P=0.618). Conclusion: Early administration of steroids on patients with M. pneumoniae pneumonia reduced the duration of fever, but there was no difference in duration of admission and x-ray deterioration. (Allergy Asthma Respir Dis 2017;5:280-286)

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9객담 배출이 어려운 소아청소년 결핵 의심 환자에서 굴곡성 기관지 내시경검사의 유용성

저자 : 이혜진 ( Hye Jin Lee ) , 박유미 ( Yumi Park ) , 양은애 ( Eun Ae Yang ) , 김환수 ( Hwan Soo K

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 287-293 (7 pages)

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Purpose: To assess the usefulness of flexible bronchoscopy in patients with suspected pulmonary tuberculosis (PTB) who have diffi-culty in sputum expectoration. Methods: The subjects of this study were patients who were suspected of PTB and visited the Division of Pediatric Pulmonology at a tertiary hospital from April 2006 to March 2016. PTB suspects were determined by clinical symptoms, radiologic findings, and im-munologic studies. We aimed to examine the value and safety of bronchoscopy in diagnosis and differential diagnosis of PTB in PTB- suspected patients. The diagnostic criteria for PTB were defined when Mycobacterium tuberculosis was cultured in the sputum speci-men or in the bronchial washing fluid. Results: A total of 19 PTB suspects were included. One patient was diagnosed with PTB by using the sputum study. However, the re-maining 18 patients could not expectorate sputum or showed no evidence of Mycobacterium tuberculosis infection from the spu-tum study. Of the 18 patients, 15 underwent bronchoscopy. After bronchoscopy, 6 patients were diagnosed with PTB and 9 patients were diagnosed with Mycoplasma, viral, or fungal pneumonia, and tumors. For antituberculous drug resistance, there were 1 case of isoniazid (INH) resistance and 1 case of concurrent resistance to INH and prothionamide. There was no multidrug-resistant tubercu-losis. None of the patients had significant complications due to bronchoscopy. Conclusion: Flexible bronchoscopy appears to be a definitive and safe procedure for the differential diagnosis of patients suspect-ing PTB in children who have difficulty expectorating sputum. (Allergy Asthma Respir Dis 2017;5:287-293)

KCI등재

10프로게스테론 과민반응에 대한 성공적인 탈감작 사례

저자 : 김영찬 ( Young-chan Kim ) , 최국환 ( Kook-hwan Choi ) , 강동윤 ( Dong-yoon Kang ) , 손경희 (

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 5권 5호 발행 연도 : 2017 페이지 : pp. 294-297 (4 pages)

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Hypersensitivity reaction to progesterone is a rare pathologic condition which consists of autoimmune response to endogenous progesterone, known as autoimmune progesterone dermatitis, and hypersensitivity reaction to exogenous progestogen. We report the case of a 31-year-old woman with a history of whole body urticaria during exogenous progesterone supplementation for in vi-tro fertilization (IVF). She was admitted to the hospital for the diagnosis and management of progestogen hypersensitivity. An intra-dermal test with progesterone revealed positivity to 5 mg/mL of progesterone. For her next IVF, progesterone desensitization was performed in a method combining oral and intramuscular progesterone administration. After successfully achieving a target dose of 100 mg per day, the route of progesterone administration was converted to intravaginal tablet (90 mg twice a day) without any hypersensitivity reactions. (Allergy Asthma Respir Dis 2017;5:294-297)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동41회 피인용

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