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Journal of Asthma, Allergy and Clinical Immunology

  • : 대한천식알레르기학회(구 대한알레르기학회)
  • : 의약학분야  >  내과학
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  • : 연속간행물
  • : 계간
  • : 1226-8739
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  • : 알레르기(~1997)→천식 및 알레르기(1998~)

수록정보
수록범위 : 1권1호(1981)~32권4호(2012) |수록논문 수 : 1,614
천식 및 알레르기
32권4호(2012년 12월) 수록논문
최근 권호 논문
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1종설 : 장기 생존 형질세포

저자 : 이주석 ( Ju Suk Lee )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 203-206 (4 pages)

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Plasma cells are usually considered short-lived plasma cells. This view is changing because plasma cells can survive for a long time in bone marrow. Long-lived plasma cells may be important in allergy because of the persistence of immunoglobulin E in allergic animal models after immune suppression. Allergic therapies efficiently control allergic symptoms but do not provide a cure, especially in adults. Elimination of long-lived plasma cells that secrete specific immunoglobulin E may provide a cure in allergic patients. The purpose of this review is to describe the creation of long-lived plasma cells and their importance in allergic diseases.

2종설 : 알레르기질환에서의 Type 2 Innate Lymphoid Cell의 역할

저자 : 모지훈 ( Ji Hun Mo )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 207-212 (6 pages)

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Innate lymphoid cells have recently been identified to be a cell population that has morphology typical of lymphocytes but lacks rearranged antigen receptors. It can be classified into RORγt innate lymphoid cell, type 2 innate lymphoid cells and natual killer cells. Among them, type 2 innate lymphoid cells plays an important role in type 2 immunity by releasing type 2 cytokines, such as interleukin-5 and interleukin- 13, and makes a match for Th2 cell of the adaptive immune system. Type 2 innate lymphoid cells responses are initiated by interleukin-25 and interleukin-33, which are produced by several cell types, such as epithelial cells, tissue macrophages and dendritic cells. These cytokines strongly activate type 2 innate lymphoid cells, leading to the production of type 2 cytokines, including, interleukin-5 and interleukin- 13. In this review, we will discuss the characteristics and development of type 2 innate lymphoid cells and the role of type 2 innate lymphoid cells in allergic diseases in detail.

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4원저 : 소아 알레르기 환자에서 혈청 흉선과 활동화 조절 케모카인, 대식세포 유래 케모카인의 상승과 호산구 염증지표와의 연관성

저자 : 정보현 ( Bo Hyun Chung ) , 이해성 ( Hae Sung Lee ) , 서현석 ( Hyeon Seok Seo ) , 박하늘 ( Ha

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 216-223 (8 pages)

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Background: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators, but the role of the serum CCL17 and CCL22 in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of CCL17 and CCL22 between children with different manifestation of allergic diseases, such as bronchial asthma, allergic rhinitis and atopic dermatitis, to analyze relationship with blood eosinophil makers and to find clinical significance of these markers. Methods: A total of 49 children (14 bronchial asthma, 13 allergic rhinitis and 13 atopic dermatitis) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (CCL17, CCL22) levels were analyzed. We examined whether serum levels of CCL17 and CCL22 would be related to serum immunoglobulin E levels, blood eosinophils and serum eosinophil cationic protein concentrations. Results: Serum levels of CCL17 and CCL22 were significantly higher in children with bronchial asthma and atopic dermatitis than that in controls. Serum levels of CCL17 and CCL22 were significantly related to serum immunoglobulin E levels, blood eosinophil counts and serum eosinophil cationic protein concentrations with different strength in children with allergic diseases. Conclusion: Serum CCL17 and CCL22 may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum CCL17 and CCL22 might be involved in the pathophysiology of allergic diseases in children.

5원저 : 군대 훈련 중 흡입항원에 대한 감작률과 알레르기질환 유병률의 변화

저자 : 황세민 ( Se Min Hwang ) , 김희경 ( Hee Kyung Kim ) , 김성화 ( Seoung Hwa Kim ) , 강점숙 ( Ju

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 224-230 (7 pages)

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Background: The objective of this study was to evaluate changes in the prevalence of sensitization to inhalant allergens and allergic disease among young army conscripts during a 35-day military training course. Methods: Fifty-four young soldiers who conscripted into the Korean army on April 29, 2011 were enrolled after their informed consent. Their sera were sampled on day 1 to measure total immunoglobulin E and allergen-specific immunoglobulin E to common inhalant allergens using UNICAP(R) and the Multiple Allergen Simultaneous Test(R), respectively. Their sera were sampled again on day 35 to evaluate temporal changes in total immunoglobulin E and allergen-specific immunoglobulin E. Subjects were also requested to respond to the modified International Study of Asthma and Allergies in Childhood questionnaire on day 35 to evaluate the prevalence of allergic diseases. Results: The number of subjects sensitized to birch/alder increased from 1 (1.9%) to 4 (7.4%) during military training; however, the difference was not statistically significant. The status of sensitization to other allergens and serum total immunoglobulin E levels did not change significantly. Of the 54 subjects, 9 (16.7%) experienced new onset or exacerbation of allergic disease. However, most of subjects were not diagnosed with allergic diseases by a physician, nor did they receive proper treatment for their symptoms. Conclusion: A 35-day course of military training was insufficient to change the inhalant allergen sensitization status; however, some young army conscripts suffered from new onset or exacerbation of allergic diseases during military training that were not diagnosed or treated appropriately.

6원저 : MLE12 및 RAW264.7세포에서 Alternaria와 Alternariol Mycotoxin의 알레르기 염증반응 효과

저자 : 최길순 ( Gil Soon Choi ) , 김희규 ( Hee Kyoo Kim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 231-238 (8 pages)

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Background: Alternaria and their secondary metabolites, alternariol mycotoxins, may cause respiratory symptoms and asthma. Moreover, microbial compounds, such as bacterial endotoxins, act as potential contributors in such situations. Alveolar epithelial cells and macrophages appear to initiate airway inflammation through proinflammatory cytokines after exposure to aeroallergens or toxic materials. The present study investigated the effects of Alternaria and alternariol mycotoxins on inflammatory cytokines secreted from airway epithelial cells and macrophages, especially interleukin-33, interleukin-6 and tumor necrosis factor-α, which were assessed association with lipopolysaccharide. Methods: In vitro MLE12 cells and RAW264.7 cells were treated with Alternaria, alternariol monomethyl ether and alternariol at different doses for 24 hour. The levels of interleukin- 33, interleukin-6, and tumor necrosis factor-α in each cell supernatants were measured by ELISA. Then, each mycotoxin (100 ng/mL) was added to lipopolysaccharide stimulated cells and incubated with them. Cell viability was measured by flow cytometry. Results: Alternaria and alternariol mycotoxin-treated cells released pro-inflammatory cytokines partly in a dose-dependent manner. Moreover, lipopolysaccharide induced the synergic effect of mycotoxins on cytokine production by RAW264.7 cells. However, the different cytokine productions among groups were not related to cell viability. Conclusion: This study suggests that alternariol mycotoxins, such as Alternaria, would provoke airway inflammation through interleukin-33, interleukin-6 and tumor necrosis factor- α uction from epithelial cells and macrophages.

7원저 : 만성기침에 대한 한국 알레르기 전문의들의 인식과 진료 실태; 설문조사

저자 : 김상헌 ( Sang Heon Kim ) , 김세훈 ( Sae Hoon Kim ) , 송우정 ( Woo Jung Song ) , 권재우 ( Jae

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 239-253 (15 pages)

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Background: Chronic cough is a common but disabling respiratory symptom. While patients are frequently referred to allergists for the management of chronic cough, little is known about the perception and clinical practices of allergists on the management of chronic cough. Methods: We performed a questionnaire survey using e-mail and internet platform among the members of the Korean Academy of Asthma, Allergy and Clinical Immunology (n=823). The members were asked to answer the questions regarding the diagnosis and treatment of chronic cough. Results: Questionnaires were completed and returned from 154 subjects (18.7%). There was a heterogeneity in the definitions (durations) of chronic cough, and only 62 subjects (40.3%) defined chronic cough when cough lasted more than 8 weeks. Most subjects (n=131, 85.1%) felt the need for Korean guidelines on chronic cough, while only 89 subjects (57.8%) used the other guidelines in their practice. Various diagnostic tests were used for the evaluations of chronic cough, and chest radiography, paranasal sinus radiography and spirometry were the most frequently performed for the management. Upper airway cough syndrome was perceived as the most common cause of chronic cough, followed by asthma, postinfectious cough and gastroesophageal reflux disease/laryngopharyngeal reflux. Moreover, treatment patterns of these most common clinical conditions differ among studied subjects. Conclusion: There were diverse patterns in the diagnosis and treatment of chronic cough among Korean allergists. Our results could assist in establishing guidelines and health policy on chronic cough management.

8원저 : 만성 자발성 두드러기 환자에서 자가혈청 피부반응검사에 따른 검사실 소견과 증상 조절을 위한 약제의 비교

저자 : 이수경 ( Su Kyoung Lee ) , 조민호 ( Min Ho Cho ) , 김병연 ( Byeong Yeon Kim ) , 강윤성 ( Yun

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 254-258 (5 pages)

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Background: The autologous serum skin test is reported to be positive in up to 60% of patients with chronic spontaneous urticaria. However, the clinical role of autologous serum skin test is still poorly understood. Methods: We reviewed the medical records of 166 chronic spontaneous urticaria patients whose symptoms lasted for more than 6 weeks and compared their laboratory findings and medication levels according to autologous serum skin test reactivity. Results: Autologous serum skin test was positive in 69 (41.6%) chronic spontaneous urticaria patients. There were no significant differences between autologous serum skin test-positive and autologous serum skin test-negative groups in laboratory findings, such as anti-microsome antibody, anti- thyroglobulin antibody, anti-nuclear antibody, total immunoglobulin E, complement 4 level levels, rheumatoid factor, erythrocyte sedimentation rate and D-dimer. Autologous serum skin test were not related to medication levels. Eight patients (11.6%) of autologous serum skin test-positive groups and 6 patients (6.2%) of autologous serum skin test-negative groups need level 4 medication (usage of cyclosporine, dapsone or anti-immunoglobulin E monoclonal antibody) to control urticaria without statistical significance. Conclusion: Autologous serum skin test was positive in more than 40% of chronic spontaneous urticaria patients. However, laboratory findings and medication levels were not affected by autologous serum skin test reactivity.

9증례 : 수은 증기 흡입에 의한 급성 폐손상 및 급성 전신성 발진성 농포증 1예

저자 : 서현정 ( Hyun Jung Seo ) , 명유식 ( Yu Sik Myung ) , 정희재 ( Hee Jae Jung ) , 김민진 ( Min

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 259-263 (5 pages)

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Background: Inhalation of mercury vapor is very rare, but if it occurs, fatal damage, such as acute lung injury or death, may ensure. In addition, acute generalized exanthematous pustulosis due to mercury hypersensitivity has rarely been reported in the literature. We experienced a 49-year-old male patient who had been exposed to mercury vapor following burning of mercury-containing materials. Case History: The patient complained of dyspnea, fever, and systemic erythema. Physical examination revealed that he had macular erythema with tiny pustules. His body temperature was 38.3oC and a complete blood count revealed elevated leucocytes. Chest radiographs revealed diffuse airspace opacification in both lungs. Results: He was admitted to the intensive care unit and treated with oxygen, intravenous methylprednisolone 125 mg per day, and oral antihistamines. His symptoms improved and his skin lesions resolved completely with desquamation 5 days. On the eighth hospital day, intravenous methylprednisolve was tapered to 62.5 mg methyprednisolone, followed by oral methyprednisolone. He was discharged from the hospital on the 20th hospital day and is currently being followed-up with no aggravation of symptoms or relapse. Conclusion: We report a case of acute lung injury and acute generalized exanthematous pustulosis induced by inhalation of mercury vapor that was successfully treated with early avoidance and steroid therapy.

10증례 : 유전성 혈관부종 환자에서의 성공적인 제왕절개 분만 1예

저자 : 이서영 ( Suh Young Lee ) , 이승은 ( Seung Eun Lee ) , 김민혜 ( Min Hye Kim ) , 송우정 ( Woo

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 264-267 (4 pages)

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Background: Hereditary angioedema is a rare disease caused by a deficiency of C1 inhibitor and inherited in an autosomal dominant manner. It leads to episodic abdominal pain and angioedema which can be life-threatening. Associations between hereditary angioedema and pregnancy have been reported in the literature. The frequency of symptoms increases during pregnancy and the postpartum period. While complications during vaginal delivery are generally known to be rare in patients with heterditary angioedema, acute attack of heterditary angioedema may occur during Cesarean section. Case History: A 34-year-old pregnant woman was admitted for the induction of labor with suspected preeclampsia. The patient was diagnosed with hereditary angioedema 5 years ago and treated with tranexamic acid when needed. During the first trimester of pregnancy, the incidence of attacks increased but she did not take any medication. She had prophylactic tranexamic acid for 2 weeks before delivery. Emergency Cesarean section was performed due to fetal deceleration that occurred during labor induction. Results: After injection of a C1 inhibitor in the phase of anesthesia induction, delivery was successful without any complications. Conclusion: We report a case of Cesarean section delivery with a prophylactic use of a C1 inhibitor in a patient with hereditary angioedema.

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