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대한마취통증의학회(구 대한마취과학회)> Korean Journal of Anesthesiology(구 대한마취과학회지)

Korean Journal of Anesthesiology(구 대한마취과학회지) update

  • : 대한마취통증의학회(구 대한마취과학회)
  • : 의약학분야  >  마취과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 격월
  • : 2005-6419
  • : 2005-7563
  • : 대한마취과학회지(~2008)→Korean Journal of Anesthesiology(2009~)

수록정보
수록범위 : 1권1호(1968)~68권6호(2015) |수록논문 수 : 7,916
Korean Journal of Anesthesiology(구 대한마취과학회지)
68권6호(2015년 12월) 수록논문
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2Propofol as a controlled substance: poison or remedy

저자 : ( Young-tae Jeon )

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 525-526 (2 pages)

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3Postreperfusion syndrome during liver transplantation

저자 : ( Sung-moon Jeong )

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 527-539 (13 pages)

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As surgical and graft preservation techniques have improved and immunosuppressive drugs have advanced, liver trans-plantation (LT) is now considered the gold standard for treating patients with end-stage liver disease worldwide. How-ever, despite the improved survival following LT, severe hemodynamic disturbances during LT remain a serious issue for the anesthesiologist. The greatest hemodynamic disturbance is postreperfusion syndrome (PRS), which occurs at reper-fusion of the donated liver after unclamping of the portal vein. PRS is characterized by marked decreases in mean arte-rial pressure and systemic vascular resistance, and moderate increases in pulmonary arterial pressure and central venous pressure. The underlying pathophysiological mechanisms of PRS are complex. Moreover, risk factors associated with PRS are not fully understood. Rapid and appropriate treatment with vasopressors, volume replacement, or venesection must be provided depending on the cause of the hemodynamic disturbance when hemodynamic instability becomes profound after reperfusion. The negative effects of PRS on postoperative early morbidity and mortality are clear, but the effect of PRS on postoperative long-term mortality remains a matter of debate.

KCI등재 SCOPUS

4T test as a parametric statistic

저자 : ( Tae Kyun Kim )

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 540-546 (7 pages)

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In statistic tests, the probability distribution of the statistics is important. When samples are drawn from population N (μ, σ²) with a sample size of n, the distribution of the sample mean X. should be a normal distribution N (μ, σ²/n). Un-der the null hypothesis μ = μ0, the distribution of statistics z = X-μ0 σ/√n σ/√n should be standardized as a normal distribution. When the variance of the population is not known, replacement with the sample variance s² is possible. In this case, the statistics X-μ0 s/√n s/√n follows a t distribution (n-1 degrees of freedom). An independent-group t test can be carried out for a comparison of means between two independent groups, with a paired t test for paired data. As the t test is a parametric test, samples should meet certain preconditions, such as normality, equal variances and independence.

KCI등재 SCOPUS

5The combination of sugammadex and neostigmine can reduce the dosage of sugammadex during recovery from the moderate neuromuscular blockade

저자 : ( Soon Ho Cheong ) , ( Seunghee Ki ) , ( Jiyong Lee ) , ( Jeong Han Lee ) , ( My

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 547-555 (9 pages)

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Background: Sugammadex is a novel neuromuscular reversal agent, but its associated hypersensitivity reaction and high cost have been obstacles to its widespread use. In the interest of reducing the necessary dosage of sugammadex, the rever-sal time of the combined use of sugammadex and neostigmine from moderate neuromuscular blockade were investigated. Methods: The patients enrolled ranged in age from 18 to 65 years old with American Society of Anesthesiologists class 1 or 2. The subjects were randomly assigned into one of the four groups (Group S2, S1, SN, and N; n = 30 per group). The reversal agents of each groups were as follows: S2 - sugammadex 2 mg/kg, S1 - sugammadex 1 mg/kg, SN - sugammadex 1 mg/kg + neostigmine 50 μg/kg + glycopyrrolate 10 μg/kg, N - neostigmine 50 μg/kg + glycopyrrolate 10 μg/kg. The time to recovery of the train-of-four (TOF) ratio was checked in each group. Results: The time to 90% recovery of TOF ratio was 182.6 ± 88.9, 371.1 ± 210.4, 204.3 ± 103.2, 953.2 ± 379.7 sec in group S2, S1, SN and N, respectively. Group SN showed a significantly shorter recovery time than did group S1 and N (P < 0.001). However, statistically significant differences between the S2 and SN groups were not be observed (P = 0.291). No hyper-sensitivity reactions occurred in all groups. Conclusions: For the reversal from rocuronium-induced moderate neuromuscular blockade, the combined use of su-gammadex and neostigmine may be helpful to decrease the recovery time and can also reduce the required dosage of sugammadex. However, the increased incidence of systemic muscarinic side effects must be considered.

KCI등재 SCOPUS

6Effects of a fentanyl-propofol mixture on propofol injection pain: a randomized clinical trial

저자 : ( Nurcan Kizilcik ) , ( Ferdi Menda ) , ( Sevgi Bilgen ) , ( Ozgul Keskin ) , (

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 556-560 (5 pages)

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Background: Propofol injection pain is a common problem that can be very distressing for patients. We compared the effects of injection with saline followed by injection with a fentanyl-propofol mixture, injection with fentanyl followed by a propofol injection, and injection with saline followed by propofol alone on propofol injection pain. Methods: The patients were assigned randomly to one of three groups. A rubber tourniquet was placed on the forearm to produce venous occlusion for 1 min. Before anesthesia induction, group C (control, n = 50) and group M (fentanylpropofol mixture, n = 50) received 5 ml of isotonic saline, while group F (fentanyl, n = 50) received 2 μg/kg of fentanyl. After the tourniquet was released, groups C and F received 5 ml of propofol and group M received 5 ml of a mixture containing 20 ml of propofol and 4 ml of fentanyl. At 10 s after the study drugs were given, a standard question about the comfort of the injection was asked of the patient. We used a verbal rating scale to evaluate propofol injection pain. Statistical analyses were performed with Student's t-tests and Fisher's exact tests; P < 0.05 was considered to indicate statistical significance. Results: The demographic data were similar among the groups. In group M, the number of patients reporting propofol injection pain was significantly lower than in groups F and C (both P < 0.001). No patient in group F or M experienced severe pain, whereas 24 patients (48%) had severe pain in group C (both P < 0.001). Conclusions: This study shows that a fentanyl-propofol mixture was more effective than fentanyl pretreatment or a placebo in preventing propofol injection pain.

KCI등재 SCOPUS

7Risk factors associated with outcomes of hip fracture surgery in elderly patients

저자 : ( Byung Hoon Kim ) , ( Sangseok Lee ) , ( Byunghoon Yoo ) , ( Woo Yong Lee ) , (

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 561-567 (7 pages)

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Background: Hip fracture surgery on elderly patients is associated with a high incidence of morbidity and mortality. The aim of this study is to identify the risk factors related to the postoperative mortality and complications following hip frac-ture surgery on elderly patients. Methods: In this retrospective study, the medical records of elderly patients (aged 65 years or older) who underwent hip fracture surgery from January 2011 to June 2014 were reviewed. A total of 464 patients were involved. Demographic data of the patients, American Society of Anesthesiologists physical status, preoperative comorbidities, type and duration of anesthesia and type of surgery were collected. Factors related to postoperative mortality and complications; as well as to intensive care unit admission were analyzed using logistic regression. Results: The incidence of postoperative mortality, cardiovascular complications, respiratory complications and intensive care unit (ICU) admission were 1.7, 4.7, 19.6 and 7.1%, respectively. Postoperative mortality was associated with preoperative respiratory comorbidities, postoperative cardiovascular complications (P < 0.05). Postoperative cardiovascular complications were related to frequent intraoperative hypotension (P < 0.05). Postoperative respiratory complications were related to age, preoperative renal failure, neurological comorbidities, and bedridden state (P < 0.05). ICU admission was associated with the time from injury to operation, preoperative neurological comorbidities and frequent intraopera-tive hypotension (P < 0.05). Conclusions: Adequate treatment of respiratory comorbidities and prevention of cardiovascular complications might be the critical factors in reducing postoperative mortality in elderly patients undergoing hip fracture surgery.

KCI등재 SCOPUS

8Clinical efficacy of the classic laryngeal mask airway in elderly patients: a comparison with young adult patients

저자 : ( Eun Mi Kim ) , ( Min-soo Kim ) , ( Bon-nyeo Koo ) , ( Jeong-rim Lee ) , ( Youn

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 568-574 (7 pages)

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Background: The elderly have been reported to show anatomical and physiologic changes in the upper airway, which might affect the supraglottic airway (SGA) performance in geriatric populations. This study aimed to evaluate the clinical efficacy of the classic laryngeal mask airway (LMA-C) in the elderly compared with young adult patients. Methods: Fifty patients aged 65.85 years (elderly group) and 50 patients aged 20.40 years (young group) who were scheduled for surgery using the LMA-C for general anesthesia were enrolled in this prospective, non-randomized, comparative study. Manipulations required during insertion, success rate, insertion time, oropharyngeal leak pressure, gastric insufflation, and intraoperative inadequate ventilation with the LMA-C were assessed. Fiberoptic evaluation was used to determine the position of the LMA-C. Results: In the elderly group, the insertion success rate on the first attempt was significantly lower than that in the young group (84 vs. 96%, P = 0.02). The insertion time in the elderly group was significantly longer than that in the young group (28.5 ± 19.6 vs. 22.2 ± 6.4 seconds, P = 0.001). However, there was no difference in oropharyngeal leak pressure or fiberoptic grade between the two groups after proper placement of the LMA-C. During the surgery, inadequate ventilation events occurred more frequently in the elderly group than in the young group (31.3 vs. 4.0%, P < 0.001). Conclusions: The clinical efficacy of the LMA-C in elderly patients was inferior to that in young adult patients. Therefore, further studies are required to determine the type of SGA that can provide excellent clinical efficacy in the geriatric population.

KCI등재 SCOPUS

9Effective dose of dexmedetomidine to induce adequate sedation in elderly patients under spinal anesthesia

저자 : ( Ki-ho Ko ) , ( In-jung Jun ) , ( Sangseok Lee ) , ( Yunhee Lim ) , ( Byunghoon

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 575-580 (6 pages)

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Background: During sedation with dexmedetomidine, a dose adjustment may be needed based on the invasiveness of the procedure, the patient's general condition, and their age. We aim here to determine the effective dose (ED) of dexmedetomidine to induce an adequate depth of sedation in elderly patients undergoing spinal anesthesia. Methods: In this study, 47 patients aged 65 years or older, American Society of Anesthesiologists physical status I or II, undergoing spinal anesthesia were included. Patients were randomly allocated into group I, II, III, IV or V according to the dexmedetomidine loading dose of 0.1, 0.3, 0.5, 0.7 and 1.0 μg/kg, respectively. After spinal anesthesia, the assigned loading dose of dexmedetomidine was infused intravenously for 10 minutes, after which infusion was maintained at a rate of 0.3 μg/kg/h for the next 10 minutes in all groups. We assessed the depth of sedation with the Ramsay sedation scale every five minutes and measured vital signs and the oxygen saturation. The ED50 and ED95 of dexmedetomidine to obtain adequate sedation (Ramsay sedation score ≥ 3) upon the completion of the loading dose were calculated with logistic regression. Results: The ED50 and ED95 of dexmedetomidine for adequate sedation were 0.29 μg/kg (95% confidence intervals [CI] 0.14.0.44) and 0.86 μg/kg (95% CI 0.52.1.20), respectively. Hypotension was frequent in groups IV, V compared to groups I, II, III (31.6 vs. 3.6%, P = 0.013). Conclusions: ED95 of dexmedetomidine loading dose for adequate sedation is 0.86 μg/kg. However, dose higher than 0.5 μg/kg can lead to hemodynamic instability.

KCI등재 SCOPUS

10Postoperative pain, nausea and vomiting among preand postmenopausal women undergoing cystocele and rectocele repair surgery

저자 : ( Sepideh Vahabi ) , ( Abolfazl Abaszadeh ) , ( Fatemeh Yari ) , ( Nazanin Youse

발행기관 : 대한마취통증의학회(구 대한마취과학회) 간행물 : Korean Journal of Anesthesiology(구 대한마취과학회지) 68권 6호 발행 연도 : 2015 페이지 : pp. 581-585 (5 pages)

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Background: Postoperative nausea and vomiting (PONV) and postoperative pain are among the most common sideeffects of surgery. Many factors, such as a change in the level of sex hormones, are reported to affect these complications. This study aimed to evaluate the probable effects of the menopause on PONV and postoperative pain. Methods: Prospective study, in which a total number of 144 female patients undergoing cystocele or rectocele repair surgery under standardized spinal anesthesia were included. Patients were divided into two equally sized sample groups of pre- and postmenopausal women (n = 72). The occurrence of PONV, the severity of pain as assessed by visual analog scale (VAS) pain score, and the quantity of morphine and metoclopramide required were recorded at 2, 4, 6, 12, 18 and 24 h after surgery. Results: The mean VAS pain score and the mean quantity of morphine required was higher among premenopausal women (P = 0.006). Moreover, these patients required more morphine for their pain management during the first 24 h after surgery compared to postmenopausal women (P < 0.0001). No difference was observed between the two groups regarding the incidence of PONV (P = 0.09 and P = 1.00 for nausea and vomiting, respectively) and the mean amount of metoclopramide required (P = 0.38). Conclusions: Premenopausal women are more likely to suffer from postoperative pain after cystocele and rectocele repair surgery. Further studies regarding the measurement of hormonal changes among surgical patients in both pre- and postmenopausal women are recommended to evaluate the effects on PONV and postoperative pain.

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