간행물

구강생물학연구 update

ORAL BIOLOGY RESEARCH

  • : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소)
  • : 의약학분야  >  기초치의학
  • : KCI등재
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  • : 연속간행물
  • : 계간
  • : 2508-2558
  • : 2508-2566
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수록정보
수록범위 : 1권0호(1978)~43권1호(2019) |수록논문 수 : 1,386
구강생물학연구
43권1호(2019년 03월) 수록논문
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Dysbiosis of oral microbiome by change of the environments induces pathogen related disease. Especially, Porphyromonas gingivalis is associated with periodontitis. Various studies have showed probiotic efficacy for periodontitis related bacteria. The purpose of this study was to investigate the therapeutic effect of probiotics on periodontitis using periodontitis induced rat model. The ligatureinduced periodontitis rats using P. gingivalis were fed the regular diet with or without probiotics for 20 days, and the periodontal status was then analyzed by micro computed tomograpy and levels of inflammatory cytokines. Also, the levels of P. gingivalis and the colonization of probiotics were analyzed by quantitative real-time polymerase chain reaction. The rat that fed on the diet containing Streptococcus thermophilus, Lactococcus lactis, and both probiotics significantly showed higher mass of the alveolar bone compared to the rat that fed on regular diet. Also, the rat that fed on the diet containing probiotics reduced the levels of inflammatory cytokines. The count of P. gingivalis was reduced in the rat fed containing probiotics. Furthermore, S. thermophilus and L. lactis were detected in the rat containing each probiotic bacterium. This study established that S. thermophilus and L. lactis may be suitable probiotics for therapeutic and preventive periodontitis.

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The objective of this study was to determine the clinical and radiographic efficacy of dehydrothermally (DHT) cross-linked collagen membrane in the treatment of peri-implant dehiscence defects through a 3-year randomized clinical trial. This study involved a total of 30 patients in the preliminary study, but only 19 patients (experimental group [DHT cross-linked collagen membrane, n=6] and control group [non-cross-linked collagen membrane, n=13]) were followed-up for 3 years after setting the baseline immediately after final prosthesis. The mean and standard deviation of each clinical measurement (probing pocket depth and width of attached gingiva) and radiological measurement (marginal bone level and clinical crown-to-implant [C/I] ratio) indices were determined and compared using the nonparametric Mann-Whitney test at the 95% confidence level. No significant complications, such as surgical site exposure and or severe infection, was observed during the follow-up period. Marginal bone loss in the experimental group and control group were 0.14±0.40 mm and 0.08±0.30 mm (p=0.631) respectively. The clinical C/I ratio change in the experimental group and control group were 0.25±0.29 mm and 0.12±0.23 mm (p=0.557) respectively. The width of attached gingiva in the experimental group and control group were 2.27±2.49 mm and 2.58±1.18 mm (p=0.732) respectively. The differences were not statistically significant. These results suggest that the experimental group and control group had similar clinical outcome, and highlight the potential of DHT crosslinked collagen membrane for guided bone regeneration around peri-implant dehiscence defects.

KCI등재

3The effect of cigarette smoking on Porphyromonas gingivalis, a crucial periodontal pathogen

저자 : Junghoon Shin , Seok-woo Lee

발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 간행물 : 구강생물학연구 43권 1호 발행 연도 : 2019 페이지 : pp. 17-22 (6 pages)

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Smoking is implicated as one of the most significant risk factors for periodontal disease. The objective of this study was to examine the effect of cigarette smoke extract (CSE), on cultivation of and protein production by Porphyromonas gingivalis, a major periodontal pathogen. P. gingivalis were cultivated in the presence of CSE (0%, 2.5%, 5%, and 10%) solution, and their growth was measured by optical density. In addition, expression pattern of proteins produced by P. gingivalis under CSE influence, was examined by sodiumdodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). According to the results, the growth of P. gingivalis was inhibited by CSE in dose-dependent mode. SDS-PAGE analyses revealed minor difference in expression pattern of proteins. Results of this study suggest that CSE imposes an inhibitory influence on growth of P. gingivalis, and is capable of modulating protein expression in P. gingivalis.

KCI등재

4Long-term evaluation of the prognosis of straight and tapered implant with resorbable blast media surface: Retrospective clinical study

저자 : Won-woong Jang , Dong-woo Kang , Young-kyun Kim

발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 간행물 : 구강생물학연구 43권 1호 발행 연도 : 2019 페이지 : pp. 23-31 (9 pages)

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To evaluate the clinical effectiveness of the straight (Osstem GS II) and tapered body (Osstem GS III) implant system. The survival rate and marginal bone loss of 101 implants placed in 36 patients were evaluated retrospectively. In Department of Oral and Maxillofacial Surgery, Seoul National University Bundang Hospital analyzed the medical records of patients who had completed the implant placement between 2005 and 2010. Sex, implant location, diameter and length were investigated. Also, implant survival rate, marginal bone loss, complications were analyzed. The amount of marginal bone loss was measured at 1 year after prosthetics placement and at the last follow up, by panorama and periapical radiography. An independent t-test was used for the analysis of the association of marginal bone loss of GS II and GS III (p=0.05). Out of the 101 implants, which were done on 36 people, 8 implants failed and survival rate was 92.1%. Marginal bone loss at 1 year after prosthetics placement was 0.23 mm in GS II, and 0.05 mm in GS III. At the last follow up, marginal bone loss was 0.51 mm in GS II and 0.29 mm in GS III. Statistically analyzing the long-term marginal bone loss difference between GS II and GS III implant system, the p-value was 0.756 and there was no statistically significant difference between the two. Long-term clinical outcomes of domestic implants by implant systems Osstem GS II and GS III have been satisfactory, and no significant difference in marginal bone loss was observed.

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The objective of this study was to investigate the changes of skin temperatures over the temporomandibular joint (TMJ) and clinical findings consecutively during conservative treatments in unilateral TMJ arthralgia patients. The study enrolled 31 patients with unilateral TMJ arthralgia and 26 healthy control subjects based on the Research Diagnostic Criteria for Temporomandibuar Disorders. The measurements of skin temperatures over the TMJ and clinical examinations were performed in all subjects at baseline, 2 and 4 weeks later, and patients were given conservative treatments. Thermographic examinations were performed before and after chewing activity for 5 minutes in each session. The data were analyzed by repeated-measures ANOVA. In affected TMJ, the change in temperature between before and after chewing activity was significantly high in TMJ arthralgia group and decreased after 2 and 4 weeks. Thermal asymmetry measured before chewing activity showed insignificant difference between groups. However, those measured after chewing activity were significantly high in TMJ arthralgia group and reduced to the similar level of control group after 2 and 4 weeks. After chewing activity, both skin temperature over painful TMJ and the extent of thermal asymmetry in TMJ arthralgia patients were higher than those of control group. These thermal indices of TMJ arthralgia patients were reduced in accordance with clinical improvements by conservative treatments. Consecutive thermography accompanying chewing activity which may increase TMJ pain temporarily can be a useful adjunctive technique to diagnose TMJ arthralgia and evaluate its clinical progression including level of pain.

KCI등재

6Awareness and practice of infection control by dental technicians in Jeju Province

저자 : Gyeong Pil Moon , Se-hoon Kahm , Jae-man Woo , Chan Woo Jo , Sung-joon Kim

발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 간행물 : 구강생물학연구 43권 1호 발행 연도 : 2019 페이지 : pp. 40-48 (9 pages)

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The purpose of study was to recognize and analyze the awareness and practice of infection control by dental technicians in Jeju Province. The data were acquired from on-line and off-line questionnaires filled out by 102 dental technicians. A statistical analysis was conducted by utilizing a frequency analysis, chi-squared test and one-way ANOVA by SPSS 22.0. Fifty-two of the 102 respondents (51.0%) acquired their dental technician license in Jeju Province. The subjects who had been educated on infection control during college or had supplementary education after graduation were 33 (32.4%) and 19 (18.6%), respectively. These results showed that the awareness and practice of the infection control during dental prosthesis fabrication were 2.41±1.10 and 2.12±1.31 on a Likert 5-point scale. The main reasons for the lack of awareness and practice of infection control were due to excessive amount of work, lack of infection control guideline, sense of necessity and concerns about deformation. Higher awareness and practice of infection control during prosthesis fabrication were associated with male gender and seniority of position at work. The statistically significant differences in awareness and practice of infection control were associated with type of laboratory, working time and training after college education. The practice scores were ranked higher in dental technicians with smaller sized laboratory, shorter working hour and more breaks during works. Dental technician's education level on infection control was insufficient and they had tended to practice less than their level of awareness. Therefore, an ongoing and systematic infection control training and surveillance would deem necessary.

KCI등재

7Analysis of Korea-Massive Open Online Courses in medical and dental education

저자 : Jieun Lee , Sun-kyoung Yu

발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 간행물 : 구강생물학연구 43권 1호 발행 연도 : 2019 페이지 : pp. 49-59 (11 pages)

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The objectives of this study were to analyze the status and the instructional design strategies of medical and dental courses in Korea- Massive Open Online Course (K-MOOC), and to present a practical direction for application in future dental education. Among 30 courses categorized as medical education in K-MOOC as of December 2018, only three cases were selected for this study. The courses were analyzed based on the proposed instructional design strategies for facilitating online interaction among participants-instructors, teaching assistants, and learners. In addition, this study reviewed the current status of free online dentistry courses in MOOC including K-MOOC. The number of basic medical science courses was five in total, however, the dentistry courses in K-MOOC was not offered yet. Regarding the format, the medical courses teaching format was similar to a lecture-based traditional classroom, which was characterized with one-way content delivery style. However, the current courses were appropriately designed with the proposed instructional design strategies to facilitate online interaction. In addition, MOOC platforms had 11 dentistry courses in 2018, even though most of them started to operate the courses recently. The results of this study denote current scarcity of dental MOOCs that could have educational potential benefits from well-structured courses with rich media delivered online and encourage dental educators to consider MOOCs as alternative educational opportunities. In addition, it provides the instructional design strategies that should be considered in designing new MOOCs. It also provides a practical direction for the development of personalized learning dentistry courses in K-MOOC.

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In a clinical environment, medical staffs often use their mobile phones with their bare hands, thereby possibly exposing them to bacteria contamination. Cross-contamination could occur, where bacteria may be transferred from the contaminated hands of a healthcare worker to a patient. Some studies have investigated the microbial contamination on mobile phones of healthcare workers. However, in these studies, specific bacteria were identified through general culture methods, and few studies have investigated the contamination on mobile phones of dentists. In this study, Illumina sequencing was used to identify the bacterial diversity present on mobile phones of dentists and dental hygienists. Five dentists and five dental hygienists working in a dental hospital were surveyed. Several bacterial genera were detected on the dentists' mobile phone, such as Pseudomonas spp. (52.52%), Janthinobacterium spp. (14.21%), Enterococcus spp. (9.66%), Stenotrophomonas spp. (5.68%), Streptococcus spp. (4.29%), and Acinetobacter spp. (3.15%). On the dental hygienists' mobile phones, Enterococcus spp. (32.02%), Pseudomonas spp. (23.76%), Streptococcus spp. (22.44%), Lactobacillus spp. (8.77%), Janthinobacterium spp. (3.54%), Acinetobacter spp. (1.7%), and Stenotrophomonas spp. (1.22%) were detected. In addition, 38.09% of the genera identified on the dentists' mobile phones and 25.74% of those on the hygienists' mobile phones contained pathogenic species. Bacteria associated with oral diseases, such as Streptococcus spp., Actinomyces spp., Porphyromonas spp., and Fusobacterium spp., were also detected in both groups. This study demonstrated the high rates of bacterial contamination on mobile phones used by dentists and dental hygienists and showed the possibility of contamination by infectious pathogens.

KCI등재

9Characteristics of a deep crack occurred on intact molars without restoration

저자 : Soo-jeong Hwang , Min-seock Seo

발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 간행물 : 구강생물학연구 43권 1호 발행 연도 : 2019 페이지 : pp. 66-73 (8 pages)

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The objective of this study was to investigate the characteristics of a deep crack in intact teeth with no restoration. The molars which were treated endodontically in the Department of Conservative Dentistry at Wonkwang University Daejeon Dental Hospital were screened and evaluated from January 2017 to June 2018. Clinical records of endodontically treated molars were reviewed and the molars diagnosed as cracked tooth were selected. From clinical records, only the cases where the crack line was confirmed to extend to the wall of access cavity were included in the study. Teeth with dental caries, restorations, or fractures at the time of diagnosis were excluded. General and pretreatment data of 85 cracked teeth were collected from the clinical records. The relatively deep cracks from intact molars occurred two times more in the maxillary molars than in the mandibular molars, and five times more in males than in females. Crack lines observed from access cavity wall were significantly different in maxillary and mandibular molars. The contralateral symmetrical molars of the cracked tooth had 'crack or fracture' or was 'extracted' at a higher rate than the occluding teeth. Deep cracks in intact molar had different characteristics from general cracks. In case someone has a cracked tooth, it may be important to check the condition of the contralateral tooth and consider the intervention.

KCI등재

10A retrospective analysis of emergency room visits of oral and maxillofacial surgery patients in a tertiary care hospital

저자 : Si-yeon Park , Jae-min Song , Jun-ho Lee , Jae-yeol Lee , Dae-seok Hwang , Yong-deok Kim , Sang-hun Shin , Uk-kyu Kim

발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 간행물 : 구강생물학연구 43권 1호 발행 연도 : 2019 페이지 : pp. 74-82 (9 pages)

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To investigate the present trends in the causes of patients visiting the emergency room of tertiary care hospital and were treated at the Department of Oral and Maxillofacial Surgery in order to prepare emergency room treatment guidelines. Increasing numbers of patients with damage to the oral and maxillofacial area visit the emergency room for treatment. This retrospective study analyzed 5,104 patients who had visited the emergency room of Pusan National University Yangsan Hospital and treated at the Department of Oral and Maxillofacial Surgery, between August 2012 and July 2017. The patients were divided into groups according to their injury types, such as trauma, infection, bleeding, temporomandibular joint disorders, and others. The number and frequency of patients in each type of injury group were analyzed as percentages (%) using SPSS 23.0 software. The male to female ratio of the patients visiting the emergency room was 1.98:1, with most patients aged below 10 years old. The majority of patients were in the trauma, infection, and bleeding groups. Fractures, especially mandibular fractures, were frequently present in the trauma group. In the oral and maxillofacial area, the results of the frequency, age, and type of injury treated in the emergency room from this study were not significantly different from those of other studies in the past. However, the reasons for the visit are still diverse and complex.

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