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Korean Journal of Dermatology

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수록정보
39권2호(2001) |수록논문 수 : 30
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39권2호(2001년) 수록논문
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1자외선 B 조사에 의한 사람 각질형성세포주 HaCaT 세포의 Interleukin - 1α 생산에 미치는 1 , 25 - Dihydroxyvitamin D3 의 영향

저자 : 지두현(Doo Hyun Chi) , 임연순(Yeon Soon Lim) , 장경애(Kyung Ae Jang) , 성환태(Hwan Tae Sung) , 여운철(Un Chul Yeo) , 성경제(Kyoung Jeh Sung) , 최지호(Jee Ho Choi)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 127-138 (12 pages)

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Background: Keratinocyte-derived interleukin-1 (IL-1) α is one of the key cytokines in initiation of cutaneous inflammation. Release of IL-1 α from human keratinocytes may be induced by proinflammatory stimuli including ultraviolet B (UVB) irradiation, and subsequently, keratinocyte-derived IL-1 α may exert numerous paracrine and autocrine effects. 1,25-dihydroxyvitamin D3(1,25(OH)2D3) is involved in the regulation of keratinocyte proliferation and differentiation and is also recognized to have immunoregulatory properties such as an antiinflammatory effect. Objective: The purpose of this study was to investigate the in vitro effects of 1,25-(OH) 2D3 on the production of IL-1 α by UVB irradiation in cultured human keratinocyte cell line HaCaT cells. Results: are summerized as follows; 1. The vialility of cultured HaCaT cells measured by MTS assay at 24 hours after UVB irradiation was significantly reduced at the doses of above 100 mJ/㎠ of UVB(p<0.05). 2. The secretion of IL-1 αby HaCaT cells was significantly increased at the doses of above 30 mJ/㎠ of UVB(p<0.05). UVB irradiation could not influence cm the secretion of IL-1 β by HaCaT cells. 3. At the concentrations of 10-8M and 10-6M of 1,25(OH2)D3, the production of IL-1 α by HaCaT cells(48 hours after 100 mJ/ ㎠ UVB irradiation) was significantly inhibited in tth culture supernatants and cell lysates(p<0.05). Conclusion: UVB irradiation increased the production of IL-1 α by HaCaT cells and this stimulatory effect on the production of IL-1 α induced by UVB irradiation was suppressed by 1,25-(OH)2D3. Calcipotriol(MC-903) had similar suppressive effect on the production of IL-1 α induced by UVB irradiation in HaCaT cells to that of 1,25(OH)2D3 (Korean J Dermatol 2001; 39(2): 127~138)

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2농촌 지역의 피부 질환 분포 및 질환 인식도

저자 : 서호석(Ho Seok Suh) , 정의창(Eui Chang Jung) , 장성은(Sung Eun Chang) , 서치우(Chi Woo Suh) , 박일중(Il Jung Park) , 한만희(Man Heui Han) , 김소형(So Hyung Kim) , 안세진(Se Jin Ahn) , 최지호(Jee Ho Choi) , 성경제(Kyung Jeh Sung) , 문기찬(Kee Chan Moon) , 고재경(Jai Kyoung Koh)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 139-146 (8 pages)

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Background: In many epidemiologic reports of distribution of skin diseases, the outpatients of university hospitals have been the target groups of the analysis. But there has been no epidemiologic study of dermatoses in the field of rural area. Objective: The purposes of this study were to investigate the distribution of skin diseases in rural areas and to evaluate the rural population's concept of skin disease and the attitude to their skin problems. Method: We analysed the results of interview and responses of questionnaires from 481 residents who visited the local public health centers and the free clinics in the rural areas of Kyonggi-Do and Ulsan city. Results: The results of the study are summarized as follows: l. Of 481 residents, there were 328 females and 153 males. The mean age was 56.6 years old.The residents over 50 years old formed 73.2 percent of total population. 2. The common dermatoses were tinea pedis, onychomycosis, xerosis, seborrheic keratosis, chloasma, pruritus, hand eczema, contact dermatitis, lentigo, seborrheic dermatitis in order of frequency. 3. The cutaneous fungal infection was the most common dermatoses in each study population. 4. To treat skin diseases, 51.2% of the residents visited the drug store initially. 5. The major reason of not taking dermatological care in the rural population was customary habit. 6. The 39.5% of 238 respondents have used self-treatments, and 15.5% of 90 respondents have experienced side effects of self-treatments. 7. On the question about the negative concepts of dermatoses, 61.7% of 462 respondents agreed to the statement that dermatoses look unclean. 8. Half of the 463 respondents thought that dermatologic medicine was harmful. The 50.6% of the 328 respondents had no specific reason, and 34.1% experienced gastrointestinal trouble. 9. The most favorite type of dermatologic medicine was topical agent, which was preferred especially by the group of respondents using nonmedical service including drug store. Conclusion: The distribution of the skin diseases in rural areas was similar to other reported results except the high frequency of cutaneous fungal infection. This research could be a basis on the following epidemiologic studies of the skin diseases in rural areas. It is also suggested that the educational program to improve understanding of skin diseases should be performed in the rural areas. (Korean J Dermatol 2001; 39(2): 139~146)

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3청피반성 혈관염의 임상 및 병리조직학적 연구

저자 : 장경애(Kyoung Ae Jang) , 김종혁(Chong Hyeok Kim) , 김소형(So Hyung Kim) , 최지호(Jee Ho Choi) , 성경제(Kyung Jeh Sung) , 문기찬(Kee Chan Moon) , 고재경(Jai Kyoung Koh)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 147-154 (8 pages)

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Background: Livedoid vasculitis is a distinctive dermatosis characterized by recurrent chronic ulceration and infiltrated purpuric papules on the lower limbs. Objective: The purpose of this study was aimed at evaluating the clinical and histopathological features of livedoid vasculitis. Methods: The hospital charts and histopathologic slides of patients with livedoid vasculitis diagnosed at Asan Medical Center from 1989 to 1999 were reviewed. Results: Twelve male and seven female patients were enrolled in this study (M: F=1.7: 1). The mean age at onset was 30.3 years in men and 25.3 years in women. The mean duration of illness was 3.3 years in male patients and 5.7 years in female patients. All the patients were presented with recurrent chronic ulceration and atrophic scarring. Twelve patients (63.2%) complained of severe pain and tenderness of the lesions and 5 patients (26.3%) complained of itching sensation. In three patients (15.8%), the lesions developed or aggravated in summer. Alcohol intake was aggravating factor in two patients (10.5%) and smoking was in one patient (5.3%). In five patients (26.3%), livedoid vasculitis develops in association with several diseases. Associated diseases were diabetes mellitus in 2 patients (10.5%), antiphospholipids antibody syndrome in 2 patients (10.5%), and protein S deficiency in 1 patient(5.3%). Histopathological examination revealed hyalinized blood vessels, partial to complete obstruction of dermal blood vessels with fibrinoid thrombi, endothelial swelling, and extravasation of RBCs in upper and mid-dermis. Panniculitis-like feature was common finding (73%). In six patients (31%), moderate to severe inflammatory reaction was observed in dermis. Five patients were treated with aspirin, dipyridamole, and pentoxifylline, and among them, only l patient (20%) were improved. All the treatment response including pentoxifylline alone, or pentoxifylline plus aspirin, dipyridamole, or corticosteroid was unsatisfactory. In cases of three patients whom were treated with low-dose danazol, all the patients (l00%) showed marked improvement. One patient was treated with dapsone with improvement. Conclusion: Livedoid vasculitis is a distinct dermatosis with characteristic clinico-pathological features. Low-dose danazol or dapsone may be useful therapeutic options in this intractable disease. (Korean J Dermatol 2001; 39(2): 147~154)

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4풍진의 임상 및 병리조직학적 고찰

저자 : 원지연(Jee Youn Won) , 전영민(Young Min Jeon) , 송은섭(Eun Sup Song)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 155-160 (6 pages)

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Background: Although rubella is a mild exanthematous viral infection and its incidence has been greatly decreased after effective vaccination, epidemics of rubella has been noted at 5- to 7-year intervals. But there has been few report about the clinical and histopathologic study of rubella in Korean literatures. Objective: The purpose of this study was to review the clinical and histopathologic characteristics of rubella of 1996 outbreak. Methods: We reviewed the clinical features and histopathologic findings in 50 patients diagnosed as rubella in Department of Dermatology, Presbyterian Medical Center from January 1996 through to May 1996. Results: 1. The male-female ratio was 1:1.17. The age distribution was 13-32 years and 72% of patients were aged 16-25 years. 2. Erythematous maculopapular rash on whole body was developed in all patients. Eighty two percent of the patients had fever and lymphadenopathy, and 36% of the patients had petechiae of soft palate. The main prodromal symptoms were sore throat (50%), headache (34%), and upper respiratory symptoms(22%), as order of frequency. 3. Positive serologic test for rubella IgM antibody was 79.5%. 4. The most common abnormal laboratory finding was leukopenia(58%), and followed by positive ASO(34%), the presence of atypical lymphocytes(21%), and thrombocytopenia(8%). 5. Histologically, epidermal changes were mild to moderate vacuolopathy(92.3%), the presence of dyskeratotic cells(30.8%), spongiosis(23.1%), and exocytosis(15.4%). Dermal findings were mild superficial perivascular lymphohistiocytic infiltration (100%), upper dermal edema (53.8%), perivascular edema(38.4%), pigmentary incontinence(30.8%), and the presence of extravasated RBC(23.1%). Eosinophil infiltration (15.4%) and the presence of large nucleated lymphocytes (92.3%) were also observed. Conclusions: According to the results of our study about rubella outbreak in 1996, clinical signs and symptoms were similar to those of previously described, Histologically, superficial perivascular dermatitis with mild to mederate vacuolar interface change was a main feature and large nucleated lymphocytes were frequently noted. (Korean J Dermatol 2001; 39(2): 155~160)

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5배양 인체 각질형성세포에서 Nerve Growth Factor ( NGF ) 수용체 발현과 NGF 가 세포 증식에 미치는 영향에 관한 연구

저자 : 류지호(Ji Ho Ryou) , 임덕우(Tuk Woo Lim) , 박재경(Jai Kyung Park) , 김낙인(Nack In Kim)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 161-167 (7 pages)

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Background: Nerve growth factor (NGF) is a neurotrophic polypeptide necessary for the survival and growth of some central neurons, as well as sensory afferent and sympathetic neurons. In addition to its actions on the nervous system, it also has a significant biologic effects on cells of the immune-inflammatory compartment. Recent studies suggest that NGF is an important autocrine growth factor and survival factor for keratinocytes which express both high- and low-affinity receptors for NGF. Objective: The purpose of this study is to detect NFG receptors an cultured human keratinocytes and to evaluate the effect of NGF on proliferation of cultured human keratinocytes. Methods: Cultured human keratinocytes were examined for the expression of high affinity receptor TrkA and low affinity receptor p75 by Northern blot, Western blot and immunocytochemistry, The effects of NGF on proliferation of cultured human keratinocytes were also evaluated. To specify the NGF effect on proliferation of human keratinocytes, excess of anti-NGF neutralizing polyclonal antibody was added. Results: 1) NGF significantly stimulated the proliferation of keratinocytes in both 1% of keratinocyte growth supplement (KGS)-added medium (100ng/ml) and 0.2% KGS-added media(50, 100, 500ng/ml), (p<0.05). The cell number was dose-dependently increased in 0.2% KGS-added media. 2) Whenever we added 500 ng/ml of anti-NGF polyclonal antibody to the growth media, the cell number was statistically higher in 100ng/ml NGF-added group of 1% KGS-added medium, but there was not any statistical significance in 0.2% KGS-added media group. 3) Immunocytochemical staining with specific antibodies to TrkA and p75 revealed positive findings for these receptors, but TrkB and TrkC were not detected. 4) We could not detect both the mRNA and protein of TrkA and p75 by Northern and Western blot methods. Conclusion: These results suggest that both high affinity- and low affinity receptors for NGF are expressed in cultured human keratinocytes and NGF can induce keratinocyte proliferation. (Korean J Dermatol 2001; 39(2): 161~167)

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6진균학적 검사 및 random amplified polymorphic DNA analysis 에 의한 피부사상균의 동정과 미동정 원인에 대한 분석

저자 : 김정애(Jeong Aee Kim) , 문상은(Sang Eun Moon) , 권태은(Tae Eun Kwon) , 유희준(Hee Joon Yu) , 조백기(Baik Kee Cho) , 이광훈(Kwang Hoon Lee) , 안규중(Kyu Joong Ahn) , 윤종현(Jong Hyun Yoon)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 168-175 (8 pages)

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Background: Dermatophytes are usually identified based on their characteristic morphologies and physiological tests. However, identification is often delayed and problematic for atypical isolates. Recently, random amplified polymorphic DNA (RAPD) analysis was successfully performed for the identification of dermatophyes. Objective: This study was performed to identify clinical isolates which eould not be identified previously. The causes of unidentification were analysed and the merits and demerits of RAPD analysis were evaluated. Methods: Thirty-six clinical isolates and 14 standard strains were included in this study. Seven 24, T. rubrum; 2, T. mentagrophytes; 2, T. raubitschekii. Four were considered as atypical strains of T. rubrum, and another 4 as non-dermatophytic moulds. This results were confirmed by RAPD analysis. Conclusion: RAPD analysis was useful for the identification of dermatophytes, especially the atypical strains. However, non-dermatophytic mould could not be identified by RAPD analysis. RAPD analysis was considered as a supplementary method to the conventional mycological studies for the identification of dermatophytes. (Korean J Dermatol 2001; 39(2): 168~175)

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7나환자의 피부병변에서 inducible Nitric Oxide Synthase 와 Cyclooxygenase - 2 의 발현

저자 : 김명화(Myung Hwa Kim) , 최유원(Yoo Won Choi) , 최혜영(Hae Young Choi) , 명기범(Ki Bum Myung)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 176-182 (7 pages)

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Background: Nitric oxide (NO) produced by activated macrophages through the action of iNOS is the key molecule in the killing mycobacterium. Prostaglandins produced by the action of COX-2, also, are the important mediators of inflammation and other pathophysiologic process. A complex relationship is emerging with regard to "cross-talk" between the NO and COX-2 pathways. Objective: The purposes of this study were to investigate the expression of iNOS and COX-2 across the spectrum of leprosy in the paraffin-embedded skin lesions, to demonstrate the interaction between iNOS and COX-2 expression, and to demonstrate the differences in the cell types expressing the iNOS or COX-2. Method: In the paraffin-embedded skin lesions of 30 new cases of leprosy(TT, n=4; BT, n=4; BL, n=7; LL, n=l5), iNOS and COX-2 expression were detected by using immunohistochemical staining. Results: iNOS expression was 2.0-55.8%(mean 15.9%) and the level of expression of iNOS in TT(31.2%) and BT(32.6%) lesions was significantly higher than that of BL(11.1%) and LL(8.6%)  lesions(p<0.05). COX-2 expression was 3.6-74.5%(mean 27.1%) and the level of expression of COX-2 in TT(59.2%) lesions was significantly higher than that of BT, BL and LL lesions(p<0.05). There was positive correlation between iNOS and COX-2 expression, that is, the lesions which expressed high level of iNOS also expressed COX-2 highly. The correlation was statistically significant(r=0.535, p<0.05). The overall level of COX-2 expression (27.1%) was higher than that of iNOS expression (15.9%), and when compared the expression of them across the spectrum of leprosy, COX-2 expressed higher than iNOS in TT and LL lesions.Conclusion: Both iNOS and COX-2 were expressed in all types of leprosy skin lesions and the level of iNOS expression in TT and BT lesions was significantly higher than that of BL and LL lesions. The level of expression of COX-2 in TT lesions was significantly higher than that of BT, BL and LL lesions. These results suggest that iNOS and COX-2 have important roles in anti-mycobacterial activities in leprosy lesions. The positive correlation between iNOS and COX-2 expression suggests that NO and COX-2 might interact synergistically or additively rather than suppress each other. (Korean J Dermatol 2001; 39(2): 176~182)

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8한국인 건선 환자에서 HLA - Cw 0602 와 건선의 임상 양상과의 연관성에 관한 연구

저자 : 남상호(Sang Ho Nam) , 김철우(Chul Woo Kim) , 김상석(Sang Seok Kim) , 김광호(Kwang Ho Kim) , 이경화(Kyung Wha Lee) , 김광중(Kwang Joong Kim)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 183-189 (7 pages)

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Background: HLA-Cw6 has the strongest individual association with psoriasis in many racial groups, and associations with the positive family history and early age at onset have been noted in many studies. Objective: The aim of this study was to investigate whether Cw6 correlate with the clinical parameters of Korean psoriatic patients. Methods: One hundred and twelve unrelated patients with psoriasis, and 166 healthy controls were examined with regard to Cw*0602, using a PCR-SSP method. We divided the patients into two groups according to Cw*0602 positivity, and compared two groups with reference to several clinical parameters. Results: The results are summarized as follows: 1. Cw*0602 was found in 69.6% of the 112 patients, but only in 9.0% of the 166 healthy controls (p<0.05, RR=23.l). 2. The presence of Cw*0602 correlated with early age at onset (26.1 vs. 32.5 years, p<0.05), and Cw*0602 was present in 75.0% of the patients with early onset(p<0.05, RR=30.2). 3. The presence of Cw*0602 did not correlate with a positive family history of psoriasis among the first-degree relatives, but correlated with an overall positive family history (p<0.05). 4. There were no positive correlations with arthritis, the history of inpatient treatment, the clinical type of psoriasis, and onset or exacerbation after upper respiratory infection. Conclusion: The presence of Cw*0602 correlated with a positive family history for psoriasis and early age at onset, but did not correlate with arthritis, the history of inpatient treatment, the clinical type of psoriasis, and onset or exacerbation after upper respiratory infection. (Korean J Dermatol 2001; 39(2): 183~189)

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9인체 모낭기관배양에서 substance P 가 모발성장에 미치는 영향

저자 : 손인범(In Bum Sohn) , 이원수(Won Soo Lee)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 190-198 (9 pages)

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Background: In vitro, some neuropeptides, including substance P(SP), act as a growth factor. The cyclic growth of the richly innervated hair follicle offers a model for probing such functions in a complex, developmentally regulated tissue interaction system under the physiologic condition. Dissecting the role of neuropeptides in this system may also reveal as yet obscure neural mechanisms of hair growth control. Objective: The purpose of this study was to investigate the effect of SP on human hair growth using a recently described model in which isolated hair follicles are grown in vitro.Methods:After the healthy human hair follicles without any visible damage were collected, they were cultured in DMEM with several combination of supplements including insulin, hydrocortisone, sodium selenite, human transferrin, fetal bovine serum at 37℃ in an atmosphere of 5% CO2 /95% air incubator, and SP was added to the media. The culture media were supplemented with final concentration of 10-6,10-7,10-8 M SP dissolved in DMEM. The results were evaluated by measuring linear hair fiber growth and hair follicle morphology on light microscopy and electron microscopy and by measuring radioisotope uptake of [methyl-3H] thymidine and [U-14C] leucine of hair follicle. Results: The following results were obtained from this study. 1. SP did not have an statistically significant effect on the rate of linear hair growth in cultured hair follicles. However, it prolonged the anagen stage of hair cycle. 2. We could not find morphological differences of hair follicles cultured in SP groups compared with those cultured in control group. 3. DNA and protein synthesis in hair follicles increased steadily for 5 days of culture. Conclusion: From the results, we can conclude that SP has growth-stimulatory effect and especially prolongs the duration of anagen phase without affecting the rate of linear hair growth. (Korean J Dermatol 2001; 39(2): 190~198)

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10퇴행 과정을 보이는 운륜 선천성 모반 1 예

저자 : 이주한(Joo Han Lee) , 장인강(In Gang Jang) , 김성욱(Sung Wook Kim) , 조백기(Baik Kee Cho)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 39권 2호 발행 연도 : 2001 페이지 : pp. 199-202 (4 pages)

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Halo congenital news is a condition in which halo formation is associated with congenital nevocellular nevus. Both humoral and cell-mediated immunity have been implicated to be involved in halo formation. We described a 8-year-old boy with halo congenital nevus characterized by the unique histologic location of inflammatory cells. He has no personal and familial history of vitiligo, dysplastic nevus, melanoma or autoimmune disease. Histologically, the present case of halo congenital nevus undergoing spontaneous regression showed a marked inflammatory infiltrate with remnants of original nevus cell nests in the upper dermis, whereas no inflammatory infiltrate was present in the deep dermis. Most of inflammatory cells were T-cells. (Korean J Dermatol 2001;39(2): 199~202)

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